Anaplastic large cell lymphoma laboratory findings: Difference between revisions

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{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Overview==
Laboratory tests for anaplastic large cell lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[flow cytometry]], [[FISH]], [[immunohistochemistry]], and [[immunophenotyping]].
Laboratory tests for anaplastic large cell lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[flow cytometry]], [[FISH]], [[immunohistochemistry]], and [[immunophenotyping]].<ref name="ALK+/ALK-">{{cite web|url=http://www.bloodjournal.org/content/111/12/5496?sso-checked=true|title=ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project}}</ref> <ref> Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: An Underrecognized Aggressive Lymphoma. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2012/529572/#B1 Accessed on October 13, 2015</ref><ref>Dovepress. Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with involvement of the urinary bladder: a case report and review of literature
===Laboratory Findings<ref name="ALK+/ALK-">{{cite web|url=http://www.bloodjournal.org/content/111/12/5496?sso-checked=true|title=ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project}}</ref>===
. https://www.dovepress.com/anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-wit-peer-reviewed-article-OTT Accessed on October 13, 2015</ref>
Laboratory tests for anaplastic large cell lymphoma include:
===Laboratory Findings===
Laboratory tests for anaplastic large cell lymphoma include:<ref name="ALK+/ALK-">{{cite web|url=http://www.bloodjournal.org/content/111/12/5496?sso-checked=true|title=ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project}}</ref> <ref> Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: An Underrecognized Aggressive Lymphoma. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2012/529572/#B1 Accessed on October 13, 2015</ref><ref>Dovepress. Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with involvement of the urinary bladder: a case report and review of literature
. https://www.dovepress.com/anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-wit-peer-reviewed-article-OTT Accessed on October 13, 2015</ref>
* [[Complete blood count]] (CBC)
* [[Complete blood count]] (CBC)
:* [[Anemia]]
:* [[Anemia]]
Line 12: Line 14:
:* Increased [[LDH]]  
:* Increased [[LDH]]  
* [[Flow cytometry]]
* [[Flow cytometry]]
* Fluorescence in situ hybridization ([[FISH]]) <ref> Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: An Underrecognized Aggressive Lymphoma. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2012/529572/#B1 Accessed on October 13, 2015</ref>
* Fluorescence in situ hybridization ([[FISH]])
:* Negative for the Epstein-Barr virus ([[EBV]])
:* Negative for the Epstein-Barr virus ([[EBV]])
* [[Immunohistochemistry]]:  
* [[Immunohistochemistry]]:  
:* Negative for human herpes virus-8 (HHV8)
:* Negative for human herpes virus-8 (HHV8)
* Immunophenotyping<ref>Dovepress. Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with involvement of the urinary bladder: a case report and review of literature
* Immunophenotyping
. https://www.dovepress.com/anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-wit-peer-reviewed-article-OTT Accessed on October 13, 2015</ref>
:* Strongly immunoreactive for [[CD30]], Anaplastic lymphoma kinase (ALK), EMA, and [[vimentin]]
:* Strongly immunoreactive for [[CD30]], Anaplastic lymphoma kinase (ALK), EMA, and [[vimentin]]
:* Negative for AE1/AE3, CK20, CK7, CK5/6, P63, [[SMA]], [[HMB-45]], pan-Melan, S-100, Myo D1, [[synaptophysin]], [[CD56]], [[desmin]], [[CD15]], [[CD20]], Pax-5, and [[CD3]]
:* Negative for AE1/AE3, CK20, CK7, CK5/6, P63, [[SMA]], [[HMB-45]], pan-Melan, S-100, Myo D1, [[synaptophysin]], [[CD56]], [[desmin]], [[CD15]], [[CD20]], Pax-5, and [[CD3]]

Revision as of 18:58, 16 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Laboratory tests for anaplastic large cell lymphoma include complete blood count (CBC), blood chemistry studies, flow cytometry, FISH, immunohistochemistry, and immunophenotyping.[1] [2][3]

Laboratory Findings

Laboratory tests for anaplastic large cell lymphoma include:[1] [4][5]

  • Blood chemistry studies
  • Negative for the Epstein-Barr virus (EBV)
  • Negative for human herpes virus-8 (HHV8)
  • Immunophenotyping

References

  1. ↑ 1.0 1.1 "ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project".
  2. ↑ Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: An Underrecognized Aggressive Lymphoma. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2012/529572/#B1 Accessed on October 13, 2015
  3. ↑ Dovepress. Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with involvement of the urinary bladder: a case report and review of literature . https://www.dovepress.com/anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-wit-peer-reviewed-article-OTT Accessed on October 13, 2015
  4. ↑ Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: An Underrecognized Aggressive Lymphoma. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2012/529572/#B1 Accessed on October 13, 2015
  5. ↑ Dovepress. Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with involvement of the urinary bladder: a case report and review of literature . https://www.dovepress.com/anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-wit-peer-reviewed-article-OTT Accessed on October 13, 2015

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