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{{familytree | | | | A02 | | | | | | A03 | | | | | | | A02=<div style="width: 25em; padding:0.5em;">'''Hairy cell leukemia'''</div>|A03=<div style="width: 25em; padding:0.5em;">'''Hairy cell leukemia variant'''</div>}}
{{familytree | | | | A02 | | | | | | A03 | | | | | | | A02=<div style="width: 25em; padding:0.5em;">'''Hairy cell leukemia'''</div>|A03=<div style="width: 25em; padding:0.5em;">'''Hairy cell leukemia variant'''</div>}}
{{familytree|boxstyle= border-top: 0px; | | | | A02 | | | | | | A03 | | | | | | | | | A02=<div style="width: 25em; padding:0.5em;text-align:left">'''90 - 95'''<br>'''4 : 1 (M : F)'''<br>'''50 - 55'''<br>'''Decreased'''<br>'''Anemia in 85% of the cases'''<br>'''Thrombocytopenia in 80% of the cases'''<br>'''Mature B cell, CD11c +, CD103 +, CD25 +'''<br>'''DBA.44 + Cyclin D1 + Annexin A1 +'''<br>'''BRAFV600E mutation'''</div>|A03=<div style="width: 25em; padding:0.5em; text-align:left">'''5 - 10 '''<br>'''2 : 1 (M : F)'''<br>'''>70'''<br>'''Normal range'''<br>'''Often normal range'''<br>'''Often normal range'''<br>'''Mature B cell, CD11c +, CD103 +, CD25 -'''<br>'''DBA.44 + Cyclin D1 + Annexin A1 -'''<br>'''BRAF wild type'''</div>}}
{{familytree|boxstyle= border-top: 0px; | | | | A02 | | | | | | A03 | | | | | | | | | A02=<div style="width: 25em; padding:0.5em;text-align:left">
* '''Occurs in approximately 95% of the cases'''<br>
* '''The male to female ratio is approximately 4 to 1'''<br>
* '''The median age at diagnosis is 55 years'''<br>'''Less than 10% lymphocytosis on peripheral blood smear'''<br>'''Decreased level of monocyte on peripheral blood smear'''<br>'''Decreased hemoglobin level in approximately 85% of the patients'''<br>'''Thrombocytopenia is present in approximately 80% of the patients'''<br>'''CD103 +, CD11c +, CD25 +'''<br>'''DBA.44 + Cyclin D1 + Annexin A1 + on immunohistochemistry'''<br>'''Presence of BRAF V600E mutation on cytogenetic tests'''</div>
|A03=<div style="width: 25em; padding:0.5em; text-align:left">'''Occurs in approximately 5% of the cases '''<br>'''The male to female ratio is approximately 2 to 1'''<br>'''The median age at diagnosis is greater than 70 years.'''<br>'''Less than 10% lymphocytosis on peripheral blood smear'''<br>'''Normal level of monocyte on peripheral blood smear'''<br>'''Normal hemoglobin level in most of the patients'''<br>'''Normal platelets count in most of the patients'''<br>'''CD103 +, CD11c +, CD25 - on immunophenotype'''<br>'''DBA.44 + Cyclin D1 + Annexin A1 - on immunohistochemistry'''<br>'''Presence of BRAF wild type on cytogenetic tests'''</div>}}
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The median age at diagnosis is 55 years.

Revision as of 18:50, 19 October 2015

 
 
 
 
 
 
 
Hairy cell leukemia classification
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Hairy cell leukemia
 
 
 
 
 
Hairy cell leukemia variant
 
 
 
 
 
 
 
 
 
  • Occurs in approximately 95% of the cases
  • The male to female ratio is approximately 4 to 1
  • The median age at diagnosis is 55 years
    Less than 10% lymphocytosis on peripheral blood smear
    Decreased level of monocyte on peripheral blood smear
    Decreased hemoglobin level in approximately 85% of the patients
    Thrombocytopenia is present in approximately 80% of the patients
    CD103 +, CD11c +, CD25 +
    DBA.44 + Cyclin D1 + Annexin A1 + on immunohistochemistry
    Presence of BRAF V600E mutation on cytogenetic tests
 
 
 
 
 
Occurs in approximately 5% of the cases
The male to female ratio is approximately 2 to 1
The median age at diagnosis is greater than 70 years.
Less than 10% lymphocytosis on peripheral blood smear
Normal level of monocyte on peripheral blood smear
Normal hemoglobin level in most of the patients
Normal platelets count in most of the patients
CD103 +, CD11c +, CD25 - on immunophenotype
DBA.44 + Cyclin D1 + Annexin A1 - on immunohistochemistry
Presence of BRAF wild type on cytogenetic tests
 
 
 
 
 
 
 
 




The median age at diagnosis is 55 years.