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* '''Occurs in approximately 95% of the cases'''<br>
* '''Occurs in approximately 95% of the cases'''<br>
* '''The male to female ratio is approximately 4 to 1'''<br>
* '''The male to female ratio is approximately 4 to 1'''<br>
* '''The median age at diagnosis is 55 years'''<br>'''Less than 10% lymphocytosis on peripheral blood smear'''<br>'''Decreased level of monocyte on peripheral blood smear'''<br>'''Decreased hemoglobin level in approximately 85% of the patients'''<br>'''Thrombocytopenia is present in approximately 80% of the patients'''<br>'''CD103 +, CD11c +, CD25 +'''<br>'''DBA.44 + Cyclin D1 + Annexin A1 + on immunohistochemistry'''<br>'''Presence of BRAF V600E mutation on cytogenetic tests'''</div>
* '''The median age at diagnosis is 55 years'''<br>
|A03=<div style="width: 25em; padding:0.5em; text-align:left">'''Occurs in approximately 5% of the cases '''<br>'''The male to female ratio is approximately 2 to 1'''<br>'''The median age at diagnosis is greater than 70 years.'''<br>'''Less than 10% lymphocytosis on peripheral blood smear'''<br>'''Normal level of monocyte on peripheral blood smear'''<br>'''Normal hemoglobin level in most of the patients'''<br>'''Normal platelets count in most of the patients'''<br>'''CD103 +, CD11c +, CD25 - on immunophenotype'''<br>'''DBA.44 + Cyclin D1 + Annexin A1 - on immunohistochemistry'''<br>'''Presence of BRAF wild type on cytogenetic tests'''</div>}}
* '''Less than 10% lymphocytosis on peripheral blood smear'''<br>
* '''Decreased level of monocyte on peripheral blood smear'''<br>
* '''Decreased hemoglobin level in approximately 85% of the patients'''<br>
* '''Thrombocytopenia is present in approximately 80% of the patients'''<br>
* '''CD103+, CD11c+, and CD25+ on immunophenotype'''<br>
* '''DBA.44+, Cyclin D1+, and Annexin A1+ on immunohistochemistry'''<br>
* '''Presence of BRAF V600E mutation on cytogenetic tests'''</div>|
A03=<div style="width: 40m; padding:0.5em; text-align:left">
* '''Occurs in approximately 5% of the cases '''<br>
* '''The male to female ratio is approximately 2 to 1'''<br>
* '''The median age at diagnosis is greater than 70 years.'''<br>
* '''Less than 10% lymphocytosis on peripheral blood smear'''<br>
* '''Normal level of monocyte on peripheral blood smear'''<br>
* '''Normal hemoglobin level in most of the patients'''<br>
* '''Normal platelets count in most of the patients'''<br>
* '''CD103+, CD11c+, and CD25- on immunophenotype'''<br>
* '''DBA.44+, Cyclin D1+, and Annexin A1 - on immunohistochemistry'''<br>
* '''Presence of BRAF wild type on cytogenetic tests'''</div>}}
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{{familytree/end}}
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Revision as of 19:29, 19 October 2015

 
 
 
 
 
 
 
Hairy cell leukemia classification
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Hairy cell leukemia
 
 
 
 
 
Hairy cell leukemia variant
 
 
 
 
 
 
 
 
 
  • Occurs in approximately 95% of the cases
  • The male to female ratio is approximately 4 to 1
  • The median age at diagnosis is 55 years
  • Less than 10% lymphocytosis on peripheral blood smear
  • Decreased level of monocyte on peripheral blood smear
  • Decreased hemoglobin level in approximately 85% of the patients
  • Thrombocytopenia is present in approximately 80% of the patients
  • CD103+, CD11c+, and CD25+ on immunophenotype
  • DBA.44+, Cyclin D1+, and Annexin A1+ on immunohistochemistry
  • Presence of BRAF V600E mutation on cytogenetic tests
 
 
 
 
 
  • Occurs in approximately 5% of the cases
  • The male to female ratio is approximately 2 to 1
  • The median age at diagnosis is greater than 70 years.
  • Less than 10% lymphocytosis on peripheral blood smear
  • Normal level of monocyte on peripheral blood smear
  • Normal hemoglobin level in most of the patients
  • Normal platelets count in most of the patients
  • CD103+, CD11c+, and CD25- on immunophenotype
  • DBA.44+, Cyclin D1+, and Annexin A1 - on immunohistochemistry
  • Presence of BRAF wild type on cytogenetic tests
  •  
     
     
     
     
     
     
     




    The median age at diagnosis is 55 years.