Sandbox: patho3: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathogenesis== | ==Pathogenesis== | ||
* The exact cell of origin of hairy cell leukemia is still unclear, however several studies have suggested that it arises from mature memory [[B cell]]s, that are normally involved in the process of human [[immunoglobulin]]s production.<ref name="found">What is Hairy Cell Leukemia? Hairy Cell Leukemia Foundation (2015) https://www.hairycellleukemia.org/about-hcl/what-is-hairy-cell-leukemia/ Accessed on October, 19 2015</ref> | |||
==Genetics== | ==Genetics== | ||
* The most common gene involved in the pathogenesis of hairy cell leukemia is BRAF V600E mutations. | * The most common gene involved in the pathogenesis of hairy cell leukemia is BRAF V600E mutations.<ref name="wiki"> Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on Ocotber, 19 2015</ref> | ||
* The BRAF V600E mutations is '''present''' in all patients with hairy cell leukemia '''classic'''. | * The BRAF V600E mutations is '''present''' in all patients with hairy cell leukemia '''(classic)'''. | ||
* The BRAF V600E mutations is '''not present''' in patients with hairy cell leukemia '''variant'''.<ref name="wiki"> Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on Ocotber, 19 2015</ref> | * The BRAF V600E mutations is '''not present''' in patients with hairy cell leukemia '''(variant)'''. | ||
* Other genes involved in the pathogenesis of hairy cell leukemia may include:<ref name="wiki"> Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on Ocotber, 19 2015</ref> | |||
:* Under expression of | :* Under expression of chromosomes 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24. | ||
:* Over expression of chromosomes 13q31 and Xq13.3-q21 | |||
==Associated Conditions== | |||
==Gross Pathology== | ==Gross Pathology== | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
Revision as of 12:06, 20 October 2015
Overview
Pathogenesis
- The exact cell of origin of hairy cell leukemia is still unclear, however several studies have suggested that it arises from mature memory B cells, that are normally involved in the process of human immunoglobulins production.[1]
Genetics
- The most common gene involved in the pathogenesis of hairy cell leukemia is BRAF V600E mutations.[2]
- The BRAF V600E mutations is present in all patients with hairy cell leukemia (classic).
- The BRAF V600E mutations is not present in patients with hairy cell leukemia (variant).
- Other genes involved in the pathogenesis of hairy cell leukemia may include:[2]
- Under expression of chromosomes 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24.
- Over expression of chromosomes 13q31 and Xq13.3-q21
Associated Conditions
Gross Pathology
Microscopic Pathology
- ↑ What is Hairy Cell Leukemia? Hairy Cell Leukemia Foundation (2015) https://www.hairycellleukemia.org/about-hcl/what-is-hairy-cell-leukemia/ Accessed on October, 19 2015
- ↑ 2.0 2.1 Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on Ocotber, 19 2015