Oligoastrocytoma other diagnostic studies: Difference between revisions

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===Fluorescent in-situ hybridization (FISH) technique===  
===Fluorescent in-situ hybridization (FISH) technique===  
**30-70% of oligoastrocytomas show loss of heterozygosity (LOH) [[chromosome 1|1p]] and [[chromosome 19|19q]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116  }} </ref>
*[[FISH]] demonstrates deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]].<ref name=turk>{{Citation |last=Tihan |first=Tarik|last=Ersen|first=Ayca |year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref>
*[[FISH]] demonstrates deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]].<ref name=turk>{{Citation |last=Tihan |first=Tarik|last=Ersen|first=Ayca |year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref>



Revision as of 19:32, 20 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Other diagnostic studies for oligoastrocytoma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).[1]

Other Diagnostic Studies

Biopsy

  • Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.
  • On biopsy, oligoastrocytoma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.
  • Biopsy may be done at the time of surgical resection of oligoastrocytoma.
  • Biopsy may be of two types: open and stereotactic.
  • Indications for open biopsy and stereotactic biopsy are described below:[2]
Type of biopsy Indications

Open biopsy

  • Surgically resectable masses
  • Lesions in accessible and relatively “silent” areas of the brain or in areas of the brain with a mild postoperative neurologic deficit
  • Appearance consistent with tumor on the MRI
  • Large tumors exerting mass effect

Stereotactic biopsy

  • Deep-seated tumor that is not amenable to resection
  • Lesions in which the radiological and clinical findings are ambiguous
  • Diffuse or multiple lesions
  • Appearance that suggests a lymphoma, which would not require resection
  • Change in the appearance of a previously diagnosed or treated tumor
  • Assessment of tumor after treatment (to distinguish between radiation necrosis and tumor recurrence)

Fluorescent in-situ hybridization (FISH) technique

References

  1. 1.0 1.1 Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 9 October, 2015 Check date values in: |accessdate= (help)
  2. Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
  3. Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.


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