Oligoastrocytoma other diagnostic studies: Difference between revisions
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===Fluorescent in-situ hybridization (FISH) technique=== | ===Fluorescent in-situ hybridization (FISH) technique=== | ||
*30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of [[chromosome 1|1p]] and [[chromosome 19|19q]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | *30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of [[chromosome 1|1p]] and [[chromosome 19|19q]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | ||
*[[FISH]] demonstrates deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]].<ref name=turk>{{Citation |last=Tihan |first=Tarik|last=Ersen|first=Ayca |year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref> | *[[FISH]] demonstrates deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]].<ref name=turk>{{Citation |last=Tihan |first=Tarik|last=Ersen|first=Ayca |year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref><ref name="pmid10653879">{{cite journal| author=Smith JS, Perry A, Borell TJ, Lee HK, O'Fallon J, Hosek SM et al.| title=Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. | journal=J Clin Oncol | year= 2000 | volume= 18 | issue= 3 | pages= 636-45 | pmid=10653879 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10653879 }} </ref> | ||
==References== | ==References== | ||
Revision as of 20:42, 20 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Other diagnostic studies for oligoastrocytoma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).[1][2]
Other Diagnostic Studies
Biopsy
- Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.[1]
- On biopsy, oligoastrocytoma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.
- Biopsy may be done at the time of surgical resection of oligoastrocytoma.
- Biopsy may be of two types: open and stereotactic.
- Indications for open biopsy and stereotactic biopsy are described below:[3]
| Type of biopsy | Indications |
|---|---|
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Fluorescent in-situ hybridization (FISH) technique
- 30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of 1p and 19q.[4]
- FISH demonstrates deletions of chromosome 1p and 19q.[2][5]
References
- ↑ 1.0 1.1 Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015
- ↑ 2.0 2.1 Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 20 October, 2015 Check date values in:
|accessdate=(help) - ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
- ↑ Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.
- ↑ Smith JS, Perry A, Borell TJ, Lee HK, O'Fallon J, Hosek SM; et al. (2000). "Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas". J Clin Oncol. 18 (3): 636–45. PMID 10653879.