Brain abscess laboratory tests: Difference between revisions

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==Overview==
==Overview==
Most laboratory tests are not diagnostic for brain abscess.


==Laboratory Findings==
==Laboratory Findings==
Laboratory findings consistent with the diagnosis of brain abscesses include [[cerebrospinal fluid]] (CSF) analysis and [[erythrocyte sedimentation rate]] (ESR).<ref>{{Citation
Blood examinations may reveal [[inflammatory]] signs with an elevation of C-reactive proteins.<ref>{{Citation
| last1  = Hähnel
| first1 = Stefan
| lastauthoramp = yes
| title    = Inflammatory Diseases of the Brain
| publisher = Springer
| place    = Berlin, Germany
| edition = 2nd
| year    = 2009
}}</ref> Laboratory findings consistent with the diagnosis of brain abscesses include [[cerebrospinal fluid]] (CSF) analysis and [[erythrocyte sedimentation rate]] (ESR).<ref>{{Citation
| last1  = Schlossberg
| last1  = Schlossberg
| first1 = David
| first1 = David
Line 16: Line 26:
| year    = 2008
| year    = 2008
}}</ref>  
}}</ref>  
*In one particular study, 41 out out 140 patients tested deteriorated within 48 hours of lumbar puncture, and out of those 41 patients, 25 died.  
* In approximately 25% of findings, the [[CSF]] is normal or shows unspecific changes.
* Findings involving CSF are nonspecific.
** It is difficult to isolate the pathogens from the CSF due to a lack of communication of the abscess with the CSF spaces.<ref>{{Citation
* The ESR is usually elevated in the 40 – 50 range, but again, can also be normal.
| last1  = Hähnel
* Patients usually have a moderate [[leukocytosis]] (< 20k), yet up to 40% can have a normal [[WBC]] count.
| first1 = Stefan
| lastauthoramp = yes
| title    = Inflammatory Diseases of the Brain
| publisher = Springer
| place    = Berlin, Germany
| edition = 2nd
| year    = 2009
 
}}</ref>
* Some patients have been seen to herniate after CSF procedure.
** In one study, 41 out of 120 patients deteriorated within 48 hours, and 25 of these individuals died.  
* There is a moderate increase in ESR.<ref>{{Citation
| last1  = Schlossberg
| first1 = David
| lastauthoramp = yes
| title    = Clinical Infectious Disease
| publisher = Cambridge University Press
| place    = New York, New York
| edition = 1st
| year    = 2008


* Obtaining tissue is demonstrates the pathogen in close to 100% of cases.
}}</ref>   


==References==
==References==

Revision as of 17:52, 30 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Most laboratory tests are not diagnostic for brain abscess.

Laboratory Findings

Blood examinations may reveal inflammatory signs with an elevation of C-reactive proteins.[1] Laboratory findings consistent with the diagnosis of brain abscesses include cerebrospinal fluid (CSF) analysis and erythrocyte sedimentation rate (ESR).[2]

  • In approximately 25% of findings, the CSF is normal or shows unspecific changes.
    • It is difficult to isolate the pathogens from the CSF due to a lack of communication of the abscess with the CSF spaces.[3]
  • Some patients have been seen to herniate after CSF procedure.
    • In one study, 41 out of 120 patients deteriorated within 48 hours, and 25 of these individuals died.
  • There is a moderate increase in ESR.[4]

References

  1. Hähnel, Stefan (2009), Inflammatory Diseases of the Brain (2nd ed.), Berlin, Germany: Springer
  2. Schlossberg, David (2008), Clinical Infectious Disease (1st ed.), New York, New York: Cambridge University Press
  3. Hähnel, Stefan (2009), Inflammatory Diseases of the Brain (2nd ed.), Berlin, Germany: Springer
  4. Schlossberg, David (2008), Clinical Infectious Disease (1st ed.), New York, New York: Cambridge University Press

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