Sandbox:DDx HEENT: Difference between revisions
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* Elevated thyroglobulin level | * Elevated thyroglobulin level | ||
* HBME-1 stain +ve | * HBME-1 stain +ve and ATP5E stain +ve | ||
* Unencapsulated multifocal tumor lesions | |||
* Positive lymphatic spread | |||
* Orphan Annie eye and Psammoma bodies | |||
* Solitary mass with irregular borders and increased vascularity on U/S | * Solitary mass with irregular borders and increased vascularity on U/S | ||
| Line 23: | Line 21: | ||
* RET proto-oncogene activation | * RET proto-oncogene activation | ||
* BRAF oncogene activation | * BRAF oncogene activation | ||
* NTRK1 | * NTRK1 activation | ||
Revision as of 15:53, 1 November 2015
- 30-50 yo Caucasian women
- Ionizing radiation exposure
- Positive family history
- Asymptomatic painless neck nodule
- Elevated thyroglobulin level
- HBME-1 stain +ve and ATP5E stain +ve
- Unencapsulated multifocal tumor lesions
- Positive lymphatic spread
- Orphan Annie eye and Psammoma bodies
- Solitary mass with irregular borders and increased vascularity on U/S
- Located at the subcapsular region
- Small punctate regions of echogenicity due to calcification
- Lymph node metastases present
- RET proto-oncogene activation
- BRAF oncogene activation
- NTRK1 activation