Sandbox:DDx HEENT: Difference between revisions

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Painless thyroid nodule
* Painless thyroid nodule
 
* May have bone pain or respiratory symptoms





Revision as of 16:25, 1 November 2015

40-60 yo women


  • Painless thyroid nodule
  • May have bone pain or respiratory symptoms


  • Elevated thyroglobulin level
  • HBME-1 stain +ve and ATP5E stain +ve


  • Orphan Annie eye and Psammoma bodies
  • Unencapsulated multifocal tumor lesions
  • Positive lymphatic spread


  • Solitary mass with irregular borders and increased vascularity on U/S
  • Lytic bone lesions or multiple lung masses due to hematogenous spread
  • Rare lymph node metastases
  • RAS oncogene activation
  • PAX8-PPAR gamma 1 genes rearrangement