Sandbox:DDx HEENT: Difference between revisions

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* Invasion of capsule and surrounding parenchyma/blood vessels on true cut biopsy
* Thick calcified capsule present
* Follicular/solid growth pattern with Hürthle cells


* Elevated thyroglobulin level
* HBME-1 stain +ve and ATP5E stain +ve


 
* Hypoechoic solid solitary mass on U/S
* Orphan Annie eye and Psammoma bodies
* Unencapsulated multifocal tumor lesions
* Positive lymphatic spread
 
 
* Solitary mass with irregular borders and increased vascularity on U/S
* Lytic bone lesions or multiple lung masses due to hematogenous spread
* Rare lymph node metastases


* RAS oncogene activation
* RAS oncogene activation
* PAX8-PPAR gamma 1 genes rearrangement
* PAX8-PPAR gamma 1 genes rearrangement

Revision as of 16:37, 1 November 2015

  • 40-60 yo women
  • May have bone pain or respiratory symptoms
  • Painless thyroid nodule


  • Invasion of capsule and surrounding parenchyma/blood vessels on true cut biopsy
  • Thick calcified capsule present
  • Follicular/solid growth pattern with Hürthle cells


  • Hypoechoic solid solitary mass on U/S
  • RAS oncogene activation
  • PAX8-PPAR gamma 1 genes rearrangement
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