Sandbox:DDx HEENT: Difference between revisions

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* Extensive lymphadenopathy  
* Extensive lymphadenopathy  


* Pleomorphic giant cells separated by connective tissue septae
* Pleomorphic giant cells
* Cavernous blood filled sinuses resembling aneurysmal bone cyst
* Connective tissue septae
* Spindle cells resembling sarcoma
* Necrosis and vascular invasion
* Squamoid cells that are relatively undifferentiated but also appear epithelial with occasional focal keratinization
* Increased mitotic activity
 
* Rhabdoid inclusions
Patterns are often mixed with better differentiated cells palisading at necrotic edges and with precursor well differentiated carcinoma;
* Well-differentiated cells palisading at necrotic edges
Necrosis
Vascular invasion
Increased mitotic activity
Rhabdoid inclusions


* BRAF gene mutation
* BRAF gene mutation
* p53 gene mutation
* p53 gene mutation

Revision as of 18:09, 1 November 2015

  • 65 yo women
  • Rapidly enlarging neck mass
  • Neck pain, dyspnea, dysphagia, and hoarseness
  • Constitutional symptoms
  • Tender hard nodular goiter
  • Extensive lymphadenopathy
  • Pleomorphic giant cells
  • Connective tissue septae
  • Necrosis and vascular invasion
  • Increased mitotic activity
  • Rhabdoid inclusions
  • Well-differentiated cells palisading at necrotic edges
  • BRAF gene mutation
  • p53 gene mutation