Mesoblastic nephroma pathophysiology: Difference between revisions
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==Genetics== | ==Genetics== | ||
Translocation t(12:15)(p13;q25) that | Translocation t(12:15)(p13;q25) that generates the genetic fusion of ETV6/NTRK3 gene is involved in the pathogenesis of mesoblastic nephroma.<ref name="pmid9462753">{{cite journal | vauthors = Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH | title = A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma | journal = [[Nature Genetics]] | volume = 18 | issue = 2 | pages = 184–7 | year = 1998 | pmid = 9462753 | doi = 10.1038/ng0298-184 | url = | issn = }}</ref> | ||
==References== | ==References== | ||
Revision as of 21:12, 2 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Gross Pathology
Characteristic findings of mesoblastic nephroma include:[1]
- Solid un-encapsulated mass
- Often occurs near the renal hilum
- Tends to invade the surrounding structures and renal parenchyma
- Hemorrhage and necrosis are infrequent
Microscopic Pathology
Classic mesoblastic nephroma
- Spindle cells in fasciclesHumphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
- Infiltrative border
Cellular mesoblastic nephroma
- Plump cells with vesicular nuclei
- Well-defined border
- Mitotically active
Mixed mesoblastic nephroma
- Both classic pattern and cellular pattern areas are present
Genetics
Translocation t(12:15)(p13;q25) that generates the genetic fusion of ETV6/NTRK3 gene is involved in the pathogenesis of mesoblastic nephroma.[2]
References
- ↑ Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma
- ↑ Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.