Mesoblastic nephroma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
On gross pathology, a solid nonencapsulated [[mass]] that often occurs near the [[renal]] [[hilum]] is the characteristic finding of mesoblastic nephroma. | |||
==Gross Pathology== | ==Gross Pathology== | ||
Characteristic findings of mesoblastic nephroma include:<ref name=radio> Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma </ref> | Characteristic findings of mesoblastic nephroma include:<ref name=radio> Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma </ref> | ||
* Solid | * Solid nonencapsulated [[mass]] | ||
* Often occurs near the renal hilum | * Often occurs near the renal [[hilum]] | ||
* Tends to invade the surrounding structures and renal parenchyma | * Tends to invade the surrounding structures and [[renal]] parenchyma | ||
* Hemorrhage and necrosis are infrequent | * [[Hemorrhage]] and [[necrosis]] are infrequent | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
Revision as of 13:41, 3 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
On gross pathology, a solid nonencapsulated mass that often occurs near the renal hilum is the characteristic finding of mesoblastic nephroma.
Gross Pathology
Characteristic findings of mesoblastic nephroma include:[1]
- Solid nonencapsulated mass
- Often occurs near the renal hilum
- Tends to invade the surrounding structures and renal parenchyma
- Hemorrhage and necrosis are infrequent
Microscopic Pathology
Classic mesoblastic nephroma[2]
- Spindle cells in fascicles
- Infiltrative border
Cellular mesoblastic nephroma
- Plump cells with vesicular nuclei
- Well-defined border
- Mitotically active
Mixed mesoblastic nephroma
- Both classic pattern and cellular pattern areas are present
Genetics
Translocation t(12:15)(p13;q25) that generates the genetic fusion of ETV6/NTRK3 gene is involved in the pathogenesis of mesoblastic nephroma.[3]
References
- ↑ Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma
- ↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
- ↑ Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.