Polycythemia vera screening: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Polycythemia vera}} | {{Polycythemia vera}} | ||
{{CMG}}{{AE}}{{MJK}} | |||
==Overview== | |||
Screening for polycythemia vera by cell-based quantitative assays for ''[[JAK2|JAK2V617F]]'' mutation is recommended among patients with [[erythrocytosis]], [[thrombocytosis]], and [[monocytosis]].<ref name=Goodmorning>{{The Asco Post| JAK2 and MPL Mutation Screening: What Are the Indications and How to Interpret the Results= | http://www.ascopost.com/issues/february-15-2012/jak2-and-mpl-mutation-screening-what-are-the-indications-and-how-to-interpret-the-results.aspx = }}</ref><ref name="pmid21723416">{{cite journal| author=Tefferi A, Noel P, Hanson CA| title=Uses and abuses of JAK2 and MPL mutation tests in myeloproliferative neoplasms a paper from the 2010 William Beaumont hospital symposium on molecular pathology. | journal=J Mol Diagn | year= 2011 | volume= 13 | issue= 5 | pages= 461-6 | pmid=21723416 | doi=10.1016/j.jmoldx.2011.05.007 | pmc=PMC3157620 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21723416 }} </ref> | |||
==Screening== | |||
Screening for polycythemia vera by cell-based quantitative assays for ''[[JAK2|JAK2V617F]]'' mutation assays may be helpful among patients with the following:<ref name=Goodmorning>{{The Asco Post| JAK2 and MPL Mutation Screening: What Are the Indications and How to Interpret the Results= | http://www.ascopost.com/issues/february-15-2012/jak2-and-mpl-mutation-screening-what-are-the-indications-and-how-to-interpret-the-results.aspx = }}</ref><ref name="pmid21723416">{{cite journal| author=Tefferi A, Noel P, Hanson CA| title=Uses and abuses of JAK2 and MPL mutation tests in myeloproliferative neoplasms a paper from the 2010 William Beaumont hospital symposium on molecular pathology. | journal=J Mol Diagn | year= 2011 | volume= 13 | issue= 5 | pages= 461-6 | pmid=21723416 | doi=10.1016/j.jmoldx.2011.05.007 | pmc=PMC3157620 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21723416 }} </ref> | |||
*[[Erythrocytosis]] | |||
*[[Thrombocytosis]] | |||
*Splanchnic vein thrombosis | |||
*Unexplained ''[[BCR|BCR-ABL]]'' negative [[granulocytosis]] | |||
==References== | ==References== | ||
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{{Hematology}} | {{Hematology}} | ||
{{Hematological malignancy histology}} | {{Hematological malignancy histology}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Revision as of 15:33, 4 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Screening for polycythemia vera by cell-based quantitative assays for JAK2V617F mutation is recommended among patients with erythrocytosis, thrombocytosis, and monocytosis.[1][2]
Screening
Screening for polycythemia vera by cell-based quantitative assays for JAK2V617F mutation assays may be helpful among patients with the following:[1][2]
- Erythrocytosis
- Thrombocytosis
- Splanchnic vein thrombosis
- Unexplained BCR-ABL negative granulocytosis
References
- ↑ 1.0 1.1 Template:The Asco Post
- ↑ 2.0 2.1 Tefferi A, Noel P, Hanson CA (2011). "Uses and abuses of JAK2 and MPL mutation tests in myeloproliferative neoplasms a paper from the 2010 William Beaumont hospital symposium on molecular pathology". J Mol Diagn. 13 (5): 461–6. doi:10.1016/j.jmoldx.2011.05.007. PMC 3157620. PMID 21723416.