Sandbox: DDx Kidney mass: Difference between revisions

Revision as of 12:46, 5 November 2015

acquired cystic kidney disease cystic renal dysplasia glomerulocystic kidney medullary sponge kidney mesothelial cysts nephronophthisis simple cysts

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-* Infants and children
+* 30 yo patients
-* Abdominal discomfort, polyuria, polydipsia, and hypertension
+* Abdominal, flank, or back pain
-* Oligohydramnios, respiratory distress, and Potter sequence
+* Hematuria and hypertenstion
-* ESRD, intracranial hemorrhage, congenital hepatic fibrosis
+* ESRD at age 60
-* Bilateral cystic abdominal mass
-* Marked abdominal distention
+* Palpable, bilateral flank masses
+* Nodular hepatomegaly
-* Elevated serum creatinine and  BUN levels
+* PKD1 gene at chromosome 16
-* Serum albumin level < 3.5 g/dL
+* PKD2 gene at chromosome 4
-* Microhematuria
-* Elevated maternal alpha fetoprotein
-* Enlarged echogenic kidneys
-* Multiple bilateral microcysts, size <2cm
-* Poor corticomedullary differentiation
-* Elongated cysts arranged in a radial pattern
-* Cystic spaces, lined by cuboidal cells, and surrounded by interstitial fibrosis
-* PKHD1 gene mutation
-* Chromosome 6p
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 ==Nonmalignant causes==
-acquired cystic kidney disease autosomal dominant polycystic kidney disease autosomal recessive polycystic kidney disease cystic renal dysplasia glomerulocystic kidney medullary sponge kidney mesothelial cysts nephronophthisis simple cysts
+acquired cystic kidney disease  cystic renal dysplasia glomerulocystic kidney medullary sponge kidney mesothelial cysts nephronophthisis simple cysts