Sandbox: DDx Kidney mass: Difference between revisions

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* 30 yo patients  
* Middle aged patients  
* Abdominal, flank, or back pain
* Majority are asymptomatic
* Hematuria, hypertenstion, intracranial hemorrhage
* May have hematuria , recurrent renal calculi, and recurrent UTI 
* ESRD at age 60


* Progressive decrease in GFR
* Often unremarkable
* Elevated creatinine and BUN


* Multiple bilateral renal cysts on U/S
* Bilateral cystic dilatation of the collecting tubules on U/S
* Anechoic with well-defined imperceptible walls
* Hyperdense papillae with clusters of small stones
* "Paintbrush-like" appearance


* Palpable, bilateral flank masses
* Nodular hepatomegaly
* Fluid filled saccular expansions of glomerular capsule and renal tubule
* Lined by cuboidal epithelium
* Disconnection of the glomerular capsule
* Polyps and papillary projections
* Areas of tubular atrophy, interstitial fibrosis, and global sclerosis are present between cyst
* PKD1 gene at chromosome 16
* PKD2 gene at chromosome 4




Revision as of 13:40, 5 November 2015

  • Middle aged patients
  • Majority are asymptomatic
  • May have hematuria , recurrent renal calculi, and recurrent UTI
  • Often unremarkable
  • Bilateral cystic dilatation of the collecting tubules on U/S
  • Hyperdense papillae with clusters of small stones
  • "Paintbrush-like" appearance








Nonmalignant causes

acquired cystic kidney disease  cystic renal dysplasia glomerulocystic kidney medullary sponge kidney mesothelial cysts nephronophthisis simple cysts

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