Gestational trophoblastic neoplasia laboratory findings: Difference between revisions
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* [[Human chorionic gonadotropin]] (HCG or b-HCG) is the most common [[tumor]] marker test used to diagnose GTD<ref name=abc> Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015</ref> | * [[Human chorionic gonadotropin]] (HCG or b-HCG) is the most common [[tumor]] marker test used to diagnose GTD<ref name=abc> Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015</ref> | ||
* HCG is markedly elevated (usu. >10,000 IU)<ref name= aaa> Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015</ref> | * HCG is markedly elevated (usu. >10,000 IU)<ref name= aaa> Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015</ref> | ||
* HCG is a very sensitive test for diagnosing most gestational trophoblastic tumors | * HCG is a very sensitive test for diagnosing most gestational trophoblastic tumors | ||
* HCG is usually measured in the blood, but it can also be measured in the [[urine]] | |||
* HCG levels are much higher in women with complete [[hydatidiform mole]]s and gestational choriocarcinoma compared to HCG levels in women with a normal [[pregnancy]] | * HCG levels are much higher in women with complete [[hydatidiform mole]]s and gestational choriocarcinoma compared to HCG levels in women with a normal [[pregnancy]] | ||
* With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD | * With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD | ||
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===Kidney function tests=== | ===Kidney function tests=== | ||
===Liver function tests=== | ===Liver function tests=== | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 15:59, 6 November 2015
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Gestational trophoblastic neoplasia Microchapters |
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Differentiating Gestational trophoblastic neoplasia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Overview
Elevated serum human chorionic gonadotropin is diagnostic of choriocarcinoma.[1][2]
Laboratory Findings
Quantitative serum HCG
- Human chorionic gonadotropin (HCG or b-HCG) is the most common tumor marker test used to diagnose GTD[1]
- HCG is markedly elevated (usu. >10,000 IU)[2]
- HCG is a very sensitive test for diagnosing most gestational trophoblastic tumors
- HCG is usually measured in the blood, but it can also be measured in the urine
- HCG levels are much higher in women with complete hydatidiform moles and gestational choriocarcinoma compared to HCG levels in women with a normal pregnancy
- With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD
- With placental site tumors, the HCG level may be slightly higher than normal, but it is not considered a good marker for this type of tumor
- An HCG test can help find GTD after pregnancy or miscarriage as this hormone should not be present in the blood or urine soon afterward
Human placental lactogen (hPL)
- Human placental lactogen (hPL) is a tumor marker that may be used to follow women with placental site trophoblastic tumors. High hPL levels are found in women with some types of GTD.
Complete blood count
- Complete blood count can check for anemia from long-term (chronic) vaginal bleeding.
Kidney function tests
Liver function tests
References
- ↑ 1.0 1.1 Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015
- ↑ 2.0 2.1 Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015