Sandbox: DDx Kidney mass: Difference between revisions

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* 3-4 yo patients
1-2 yo patients
* Asymptomatic abdominal mass
Abdominal mass
* May have abdominal pain, fever, nausea/vomiting, hematuria, and hypertension
May have abdominal pain, constipation, proptosis, periorbital ecchymoses, back pain, weakness, hypertension, and subcutaneous nodules
* Beckwith-Wiedemann syndrome and WAGR syndrome
Opsoclonus myoclonus ataxia syndrome
 
* Unilateral, smooth, firm, nontender, flank mass
* Does not cross the midline
 
 
* Elevated serum creatinine and BUN
* Reduced glomerular filtration rate
* Abnormal liver function tests
* Erythrocytosis, hypercalcemia, and acquired Von Willebrand disease
 
 
 
* Large heterogeneous solid mass on U/S
* Displace adjacent structures
* Lung and lymph nodes metastasis
* Renal vein thrombosis
 
 
* Triphasic pattern consisting of tubules, solid sheets of small round cells, and stroma
* Small round blue cells, nuclear pleomorphism, and irregular nuclear membrane
* Clustered tubular structures Tubular with central clear spaces surrounded by a rim of intensely eosinophilic cytoplasm.
 
* WT1 and WT2 genes on chromosome 11
* WTX gene on chromosome X




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==Nonmalignant causes==
==Nonmalignant causes==
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying tumor renal cell carcinoma rhabdoid tumor translocation carcinoma (children) Wilms tumor of children
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying tumor renal cell carcinoma rhabdoid tumor translocation carcinoma (children) 

Revision as of 16:35, 6 November 2015

1-2 yo patients Abdominal mass May have abdominal pain, constipation, proptosis, periorbital ecchymoses, back pain, weakness, hypertension, and subcutaneous nodules Opsoclonus myoclonus ataxia syndrome




Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying tumor renal cell carcinoma rhabdoid tumor translocation carcinoma (children) 

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