Waldenström's macroglobulinemia pathophysiology: Difference between revisions
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*Infiltration of bone marrow, spleen and lymph nodes by neoplastic lymphoplasmacytic cells. | *Infiltration of bone marrow, spleen and lymph nodes by neoplastic lymphoplasmacytic cells. | ||
:*Less commonly, infiltration of liver, lungs, GI tract, kidneys, skin, eyes, and central nervous system (CNS) can also occur. | :*Less commonly, infiltration of liver, lungs, GI tract, kidneys, skin, eyes, and central nervous system (CNS) can also occur. | ||
==References== | |||
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Revision as of 19:09, 6 November 2015
The clinical manifestations of Waldenström Macroglobulinemia depend on two different factors.
- Hyperviscosity syndrome & vascular complications due to secretion of Monoclonal igM.
- IgM paraprotein occasionally has:
- Rheumatoid factor activity,
- antimyelin activity that can contribute to peripheral neuropathy, and
- Immunologically related lupus anticoagulant activity.
- Infiltration of bone marrow, spleen and lymph nodes by neoplastic lymphoplasmacytic cells.
- Less commonly, infiltration of liver, lungs, GI tract, kidneys, skin, eyes, and central nervous system (CNS) can also occur.