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==Overview==
==Overview==
People with Essential thrombocytosis are usually asymptomatic. Symptoms of ET may arise from vascular occlusion by thrombi or bleeding and may include vision disturbances, chest pain, intense burning pain in hands or feet([[erythromelalgia]]), numbness and tingling of hands and feet, [[priapism]] (persistent and painful erection of the penis). Neurologic symptoms like headache may occur but the pathophysiology is not completely understood. Rarely a family history may be present in patients with familial essential thrombocytosis.


==History and symptoms==
==History and symptoms==
Patients with a mild form of disease are usually asymptomatic. Patients may have symptoms of minimal bleeding that went unnoticed until diagnosis. Most of the symptoms are vascular, either from thrombi occluding small and large blood vessels, though any blood vessel may be involved. Symptoms depend on the blood vessel occluded and include but are not limited to the following:
*People with Essential thrombocytosis are usually asymptomatic. Patients may have symptoms of minimal bleeding that go unnoticed until diagnosis. Most of the symptoms are vascular, either from thrombi occluding small and large blood vessels, though any blood vessel may be involved. Symptoms depend on the blood vessel involved.
*Headache, dizziness
*Symptoms of vascular occlusion:  
*Vision disturbances
**[[Dizziness]]
*Chest pain
**Vision disturbances
*Intense burning pain in hands or feet(erythromelalgia)
**Chest pain
*Numbness and tingling of hands and feet
**Intense burning pain in hands or feet(erythromelalgia)
*Priapism
**Numbness and tingling of hands and feet
 
**[[Priapism]] (persistent and painful erection of the penis)
Although less common, bleeding can occur despite the increased platelet count accounting to the dysfunctional platelets. Common sites of bleeding include eyes, nose(epistaxis), gums, gastrointestinal tract, skin(bruises). The bleeding itself is usually minimal.
*Symptoms from bleeding can occur despite the increased platelet count accounting to the dysfunctional platelets. Common sites of bleeding include eyes, nose([[epistaxis]]), gums, gastrointestinal tract, skin(bruises). The bleeding itself is usually minimal.
 
*Neurologic symptoms like headache may occur but the pathophysiology is not completely understood.<ref name="pmid17210076">{{cite journal| author=Brière JB| title=Essential thrombocythemia. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 3 | pmid=17210076 | doi=10.1186/1750-1172-2-3 | pmc=PMC1781427 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17210076  }} </ref>
 
Based on the platelet counts, severity of the disease can be assessed as follows:
 
*Mild- Platelet count>500,000μL - 700,000μL
*Moderate- Platelet count>700,000μL - 900,000μL
*Severe- Platelet count >900,000μL
*Extreme- Platelet count >1,000,000μL


==References==
==References==

Revision as of 19:32, 6 November 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

People with Essential thrombocytosis are usually asymptomatic. Symptoms of ET may arise from vascular occlusion by thrombi or bleeding and may include vision disturbances, chest pain, intense burning pain in hands or feet(erythromelalgia), numbness and tingling of hands and feet, priapism (persistent and painful erection of the penis). Neurologic symptoms like headache may occur but the pathophysiology is not completely understood. Rarely a family history may be present in patients with familial essential thrombocytosis.

History and symptoms

  • People with Essential thrombocytosis are usually asymptomatic. Patients may have symptoms of minimal bleeding that go unnoticed until diagnosis. Most of the symptoms are vascular, either from thrombi occluding small and large blood vessels, though any blood vessel may be involved. Symptoms depend on the blood vessel involved.
  • Symptoms of vascular occlusion:
    • Dizziness
    • Vision disturbances
    • Chest pain
    • Intense burning pain in hands or feet(erythromelalgia)
    • Numbness and tingling of hands and feet
    • Priapism (persistent and painful erection of the penis)
  • Symptoms from bleeding can occur despite the increased platelet count accounting to the dysfunctional platelets. Common sites of bleeding include eyes, nose(epistaxis), gums, gastrointestinal tract, skin(bruises). The bleeding itself is usually minimal.
  • Neurologic symptoms like headache may occur but the pathophysiology is not completely understood.[1]

References

  1. Brière JB (2007). "Essential thrombocythemia". Orphanet J Rare Dis. 2: 3. doi:10.1186/1750-1172-2-3. PMC 1781427. PMID 17210076.


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