Sandbox: DDx Kidney mass: Difference between revisions

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* 50-70 yo males
60-70 male patients
* Asymptomatic
von Hippel-Lindau syndrome
* Incidental finding


* Palpable flank mass


Polygonal cells, clear cytoplasm, and a central nucleus
Delicate branching vasculature
"Chicken wire-like" vasculature
Hyaline bodies common




 
Chromosome 3 mutation
 
VHL gene mutation
* Heterogeneous, multifocal, well-circumscribed, large mass on CT
Gain of chromosome 5
* Less intense contrast enhancement
* Distinct fibrous capsule
* Calcification
 
* Papillary fibrovascular cores
* Foamy macrophages
* Intracellular hemosiderin
* Longitudinal nuclear groove
* Hyaline globules present
 
 
* Trisomy 7
* Trisomy 17
 


==Nonmalignant causes==
==Nonmalignant causes==
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying

Revision as of 15:46, 9 November 2015

60-70 male patients von Hippel-Lindau syndrome


Polygonal cells, clear cytoplasm, and a central nucleus Delicate branching vasculature "Chicken wire-like" vasculature Hyaline bodies common


Chromosome 3 mutation VHL gene mutation Gain of chromosome 5

Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying

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