Sandbox: DDx Kidney mass: Difference between revisions

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* 60-70 male patients
* Pale cytoplasm
* Haematuria
* Streaks of eosinophilic material
* Flank pain
* "Cobwebs" appearance
* Palpable flank mass
* Perinuclear clearing
* von Hippel-Lindau syndrome
* Psammoma bodies


 
* Multiple losses of entire chromosomes 1, 2, 6, 10, 13, 17, 21 and Y
* Polygonal cells, clear cytoplasm, and a central nucleus
* Delicate branching vasculature
* "Chicken wire-like" vasculature
* Hyaline bodies common
 
 
 
* Large heterogeneous mass
* Variable enhancement on CT due to necrosis
* Invasion of venous circulation
 
* Chromosome 3 mutation
* VHL gene mutation
* Gain of chromosome 5


==Nonmalignant causes==
==Nonmalignant causes==
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying

Revision as of 16:26, 9 November 2015

  • Pale cytoplasm
  • Streaks of eosinophilic material
  • "Cobwebs" appearance
  • Perinuclear clearing
  • Psammoma bodies
  • Multiple losses of entire chromosomes 1, 2, 6, 10, 13, 17, 21 and Y

Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying

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