Intracerebral metastases medical therapy: Difference between revisions
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===Therapeutic=== | ===Therapeutic=== | ||
====Radiation Therapy==== | ====Radiation Therapy==== | ||
*The most widely used treatment for patients with multiple brain metastases is whole brain external beam radiotherapy (WBRT).<ref name="Khuntia2015">{{cite journal|last1=Khuntia|first1=Deepak|title=Contemporary Review of the Management of Brain Metastasis with Radiation|journal=Advances in Neuroscience|volume=2015|year=2015|pages=1–13|issn=2356-6787|doi=10.1155/2015/372856}}</ref> | *The most widely used treatment for patients with multiple brain metastases is [[external beam radiotherapy|whole brain external beam radiotherapy (WBRT)]].<ref name="Khuntia2015">{{cite journal|last1=Khuntia|first1=Deepak|title=Contemporary Review of the Management of Brain Metastasis with Radiation|journal=Advances in Neuroscience|volume=2015|year=2015|pages=1–13|issn=2356-6787|doi=10.1155/2015/372856}}</ref> | ||
*Stereotactic radiosurgery is done for smaller masses. | *Stereotactic radiosurgery is done for smaller masses. | ||
*The appropriate use of WBRT can provide rapid improvements of many neurologic symptoms, improve quality of life, and may be especially beneficial in patients whose brain metastases are surgically inaccessible or when other medical considerations remove surgery from the list of appropriate options [32–34]. The use of adjuvant WBRT, following resection or radiosurgery has been proven to be effective in terms of improving local control of brain metastases, and, furthermore, the likelihood of neurologic death is decreased based on a randomized trial | |||
==References== | ==References== | ||
Revision as of 21:45, 9 November 2015
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Intracerebral metastases Microchapters |
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Differentiating Intracerebral Metastases from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Intracerebral metastases medical therapy On the Web |
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American Roentgen Ray Society Images of Intracerebral metastases medical therapy |
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Risk calculators and risk factors for Intracerebral metastases medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Medical Therapy
Symptomatic Treatment
- Corticosteroids are given to limit the effects of peritumoral edema.[1]
- Hyperosmolar agents (i.e., mannitol) can be given to reduce intracranial pressure
- Anticonvulsants are given to prevent seizures.
- Recently, methylphenidate and donepezil have been used to improve cognition, mood, and quality of life.
Therapeutic
Radiation Therapy
- The most widely used treatment for patients with multiple brain metastases is whole brain external beam radiotherapy (WBRT).[1]
- Stereotactic radiosurgery is done for smaller masses.
- The appropriate use of WBRT can provide rapid improvements of many neurologic symptoms, improve quality of life, and may be especially beneficial in patients whose brain metastases are surgically inaccessible or when other medical considerations remove surgery from the list of appropriate options [32–34]. The use of adjuvant WBRT, following resection or radiosurgery has been proven to be effective in terms of improving local control of brain metastases, and, furthermore, the likelihood of neurologic death is decreased based on a randomized trial