Sandbox: maria: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathogenesis== | ==Pathogenesis== | ||
* Medulloblastoma arises from embryonal cells, which are stem cells that are normally involved in development of the fourth ventricle. | * Medulloblastoma arises from embryonal cells, which are stem cells that are normally involved in development of the fourth ventricle.<ref>Medulloblastoma. Wikipedia (2015)https://en.wikipedia.org/wiki/Medulloblastoma#Pathogenesis Accessed on November,10 2015</ref> | ||
==Genetics== | ==Genetics== | ||
* Development of medulloblastoma is the result of multiple genetic mutations. | * Development of medulloblastoma is the result of multiple genetic mutations. | ||
| Line 18: | Line 18: | ||
:*TBR1 | :*TBR1 | ||
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==Gross Pathology== | ==Gross Pathology== | ||
==Micropathology== | ==Micropathology== | ||
* On microscopic histopathological analysis, characteristic findings of medulloblastoma include:<ref>Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015 </ref> | |||
:* Small round cell tumor | |||
:* Homer-Wright rosettes | |||
* On immunohistochemestry analysis, characteristic findings of medulloblastoma include:<ref>Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015 </ref> | |||
:* MAP2 +ve | |||
:* Synaptophysin +ve | |||
:* NSE +ve/-ve | |||
:* NF +ve/-ve | |||
:* Chromogranin +ve/-ve | |||
:* GFAP +ve/-ve | |||
:* Vimentin +ve | |||
:* Nestin +ve | |||
:* INI1 retained | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 15:36, 10 November 2015
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Medulloblastoma Microchapters |
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Diagnosis |
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Treatment |
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Case studies |
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Sandbox: maria On the Web |
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American Roentgen Ray Society Images of Sandbox: maria |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
- Medulloblastoma arises from embryonal cells, which are stem cells that are normally involved in development of the fourth ventricle.[1]
Genetics
- Development of medulloblastoma is the result of multiple genetic mutations.
- Genes involved in the pathogenesis of medulloblastoma include:
- CTNNB1
- PTCH1
- MLL2
- SMARCA4
- DDX3X
- CTDNEP
- KDM6A
- TBR1
Associated Conditions
Gross Pathology
Micropathology
- On microscopic histopathological analysis, characteristic findings of medulloblastoma include:[2]
- Small round cell tumor
- Homer-Wright rosettes
- On immunohistochemestry analysis, characteristic findings of medulloblastoma include:[3]
- MAP2 +ve
- Synaptophysin +ve
- NSE +ve/-ve
- NF +ve/-ve
- Chromogranin +ve/-ve
- GFAP +ve/-ve
- Vimentin +ve
- Nestin +ve
- INI1 retained
References
- ↑ Medulloblastoma. Wikipedia (2015)https://en.wikipedia.org/wiki/Medulloblastoma#Pathogenesis Accessed on November,10 2015
- ↑ Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015
- ↑ Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015