Intracerebral metastases pathophysiology: Difference between revisions
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Image:Metastatic adenocarcinoma - cerebellum - very low mag.jpg|<sub>Very low magnification micrograph demonstrating metastatic adenocarcinoma that was shown to be a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum seen on the image has Bergmann gliosis and purkinje cell loss.<ref name=microscopicimagesofbrainmetastasis1>Microscopic images of brain metastasis. Libre pathology 2015. http://librepathology.org/wiki/index.php/Brain_metastasis. Accessed on November 10, 2015</ref></sub> | |||
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==References== | ==References== | ||
Revision as of 15:43, 10 November 2015
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Intracerebral metastases Microchapters |
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Differentiating Intracerebral Metastases from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Intracerebral metastases pathophysiology On the Web |
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American Roentgen Ray Society Images of Intracerebral metastases pathophysiology |
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Risk calculators and risk factors for Intracerebral metastases pathophysiology |
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Overview
Pathophysiology
Pathogenesis
Gross Pathology
- Typically metastases are sharply demarcated from the surrounding parenchyme and usually there is a zone of peritumoral edema out of proportion with the tumor size.
- Common intracranial sites associated with subependymal giant cell astrocytoma include:[1]
- Cerebrum (80%)
- Cerebellum (15%)
- Brain stem (5% )
Gallery
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![This solitary brain metastasis from thyroid papillary carcinoma resulted in neurological symptoms. The thyroid primary was clinically occult. (Courtesy of Dr. Nikola Kostich, Minneapolis, MN.).[2]](/images/1/12/THYROID_PAPILLARY_CARCINOMA_METASTATIC_TO_BRAIN.jpg)
This solitary brain metastasis from thyroid papillary carcinoma resulted in neurological symptoms. The thyroid primary was clinically occult. (Courtesy of Dr. Nikola Kostich, Minneapolis, MN.).[2]
![This solitary brain metastasis from thyroid papillary carcinoma resulted in neurological symptoms. The thyroid primary was clinically occult. (Courtesy of Dr. Nikola Kostich, Minneapolis, MN.).[2]](/index.php/File:THYROID_PAPILLARY_CARCINOMA_METASTATIC_TO_BRAIN.jpg)
Microscopic Pathology
The histopathological appearance of intracerebral metastases may vary with the type of primary cancer. Common findings are listed below:[3]
- Tubule formation/glands
- Usually well-circumscribed and sharply demarcated from surrounding tissue (with the exception of melanoma metastasis)
- Mitoses
- Nuclear atypia
- Nuclear hyperchromasia
- Variation of nuclear size
- Variation of nuclear shape
Gallery
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![Very low magnification micrograph demonstrating metastatic adenocarcinoma that was shown to be a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum seen on the image has Bergmann gliosis and purkinje cell loss.[4]](/images/a/ae/Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg)
Very low magnification micrograph demonstrating metastatic adenocarcinoma that was shown to be a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum seen on the image has Bergmann gliosis and purkinje cell loss.[4]
![Very low magnification micrograph demonstrating metastatic adenocarcinoma that was shown to be a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum seen on the image has Bergmann gliosis and purkinje cell loss.[4]](/index.php/File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg)
References
- ↑ Khuntia, Deepak (2015). "Contemporary Review of the Management of Brain Metastasis with Radiation". Advances in Neuroscience. 2015: 1–13. doi:10.1155/2015/372856. ISSN 2356-6787.
- ↑ Gross image of brain metastases. Libre pathology 2015. http://librepathology.org/wiki/index.php/Brain_metastasis. Accessed on November 10, 2015
- ↑ Microscopic features of brain metastasis. Libre pathology 2015. http://librepathology.org/wiki/index.php/Brain_metastasis. Accessed on November 10, 2015
- ↑ Microscopic images of brain metastasis. Libre pathology 2015. http://librepathology.org/wiki/index.php/Brain_metastasis. Accessed on November 10, 2015