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:* Small round cell tumor | :* Small round cell tumor | ||
:* Homer-Wright rosettes | :* Homer-Wright rosettes | ||
* On immunohistochemestry analysis, characteristic findings of medulloblastoma include:<ref>Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015 </ref> | * On immunohistochemestry analysis, characteristic findings of medulloblastoma include:<ref>Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015 </ref><ref name="pmid26538622">{{cite journal |vauthors=Schmidt C |title=Targeted Therapy Makes Inroads in Medulloblastoma |journal=J. Natl. Cancer Inst. |volume=107 |issue=11 |pages= |year=2015 |pmid=26538622 |doi=10.1093/jnci/djv353 |url=}}</ref><ref>Grisold W, Soffietti R. Neuro-Oncology, Part II, Handbook of Clinical Neurology (Series editors: Aminoff, Boller, Swaab). Elsevier; 2012.</ref> | ||
:* MAP2 +ve | :* MAP2 +ve | ||
:* Synaptophysin +ve | :* Synaptophysin +ve | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 16:23, 10 November 2015
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Medulloblastoma Microchapters |
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Diagnosis |
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Treatment |
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Case studies |
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Sandbox: maria On the Web |
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American Roentgen Ray Society Images of Sandbox: maria |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
- Medulloblastoma arises from embryonal cells, which are stem cells that are normally involved in development of the fourth ventricle.[1]
Genetics
- Development of medulloblastoma is the result of multiple genetic mutations.
- Genes involved in the pathogenesis of medulloblastoma include:
- CTNNB1
- PTCH1
- MLL2
- SMARCA4
- DDX3X
- CTDNEP
- KDM6A
- TBR1
Associated Conditions
Gross Pathology
Micropathology
- On microscopic histopathological analysis, characteristic findings of medulloblastoma include:[2]
- Small round cell tumor
- Homer-Wright rosettes
- MAP2 +ve
- Synaptophysin +ve
- NSE +ve/-ve
- NF +ve/-ve
- Chromogranin +ve/-ve
- GFAP +ve/-ve
- Vimentin +ve
- Nestin +ve
- INI1 retained
References
- ↑ Medulloblastoma. Wikipedia (2015)https://en.wikipedia.org/wiki/Medulloblastoma#Pathogenesis Accessed on November,10 2015
- ↑ Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015
- ↑ Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015
- ↑ Schmidt C (2015). "Targeted Therapy Makes Inroads in Medulloblastoma". J. Natl. Cancer Inst. 107 (11). doi:10.1093/jnci/djv353. PMID 26538622.
- ↑ Grisold W, Soffietti R. Neuro-Oncology, Part II, Handbook of Clinical Neurology (Series editors: Aminoff, Boller, Swaab). Elsevier; 2012.