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| __NOTOC__
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| {{Medulloblastoma}}
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| {{CMG}} {{AE}}{{HL}}
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| ==Overview==
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| ==Pathogenesis==
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| * Medulloblastoma arises from embryonal cells, which are stem cells that are normally involved in development of the fourth ventricle.<ref>Medulloblastoma. Wikipedia (2015)https://en.wikipedia.org/wiki/Medulloblastoma#Pathogenesis Accessed on November,10 2015</ref>
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| ==Genetics==
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| * Development of medulloblastoma is the result of multiple genetic mutations.
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| * Genes involved in the pathogenesis of medulloblastoma include:
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| :*CTNNB1
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| :*PTCH1
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| :*MLL2
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| :*SMARCA4
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| :*DDX3X
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| :*CTDNEP
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| :*KDM6A
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| :*TBR1
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| ==Associated Conditions==
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| ==Gross Pathology==
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| ==Micropathology==
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| * On microscopic histopathological analysis, characteristic findings of medulloblastoma include:<ref>Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015 </ref>
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| :* Small round cell tumor
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| :* Homer-Wright rosettes
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| * On immunohistochemestry analysis, characteristic findings of medulloblastoma include:<ref>Medulloblastoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on November,10 2015 </ref><ref name="pmid26538622">{{cite journal |vauthors=Schmidt C |title=Targeted Therapy Makes Inroads in Medulloblastoma |journal=J. Natl. Cancer Inst. |volume=107 |issue=11 |pages= |year=2015 |pmid=26538622 |doi=10.1093/jnci/djv353 |url=}}</ref><ref>Grisold W, Soffietti R. Neuro-Oncology, Part II, Handbook of Clinical Neurology (Series editors: Aminoff, Boller, Swaab). Elsevier; 2012.</ref>
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| :* MAP2 +ve
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| :* Synaptophysin +ve
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| :* NSE +ve/-ve
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| :* NF +ve/-ve
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| :* Chromogranin +ve/-ve
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| :* GFAP +ve/-ve
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| :* Vimentin +ve
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| :* Nestin +ve
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| :* INI1 retained
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| ==References==
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| {{Reflist|2}}
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| [[Category:Disease]]
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| [[Category:Neurology]]
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| [[Category:Types of cancer]]
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