Intracerebral metastases historical perspective: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
Intracerebral metastases was first described by Posner and Chernik, following the largest and most comprehensive autopsy series at Memorial Sloan-Kettering Cancer Center from 1970 to 1976.<ref name=historicalperspectiveofintracerebralmetastases>{{Cite journal | *Intracerebral metastases was first described by Posner and Chernik, following the largest and most comprehensive autopsy series at Memorial Sloan-Kettering Cancer Center from 1970 to 1976.<ref name=historicalperspectiveofintracerebralmetastases>{{Cite journal | ||
| author = [[Andrew B. Lassman]] & [[Lisa M. DeAngelis]] | title = Brain metastases | journal = [[Neurologic clinics]] | volume = 21 | issue = 1 | pages = 1–23 | year = 2003 | month = February | pmid = 12690643}}</ref> | | author = [[Andrew B. Lassman]] & [[Lisa M. DeAngelis]] | title = Brain metastases | journal = [[Neurologic clinics]] | volume = 21 | issue = 1 | pages = 1–23 | year = 2003 | month = February | pmid = 12690643}}</ref> | ||
*More than a century ago, Stephen Paget advanced his “''seed and soil''” hypothesis, which suggests that the occurrence of intracerebral metastases is not random, but is secondary to certain tumor cells—“the seed”—having an attraction for the surrounding environment—“the soil”. The hypothesis envisages three principles: ''first'', that the neoplasms are composed of heterogeneous subpopulations of cells, with different characteristics; ''second'', that only a selectively “fit” subpopulation of cells will survive and multiply, invade, and migrate to other locations; and ''finally'', that the colonization depends on tumor cell “seed” and host microenvironment “soil” interactions.<ref name="RahmathullaToms2012">{{cite journal|last1=Rahmathulla|first1=Gazanfar|last2=Toms|first2=Steven A.|last3=Weil|first3=Robert J.|title=The Molecular Biology of Brain Metastasis|journal=Journal of Oncology|volume=2012|year=2012|pages=1–16|issn=1687-8450|doi=10.1155/2012/723541}}</ref> | |||
==References== | ==References== | ||
Revision as of 19:07, 10 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Historical Perspective
- Intracerebral metastases was first described by Posner and Chernik, following the largest and most comprehensive autopsy series at Memorial Sloan-Kettering Cancer Center from 1970 to 1976.[1]
- More than a century ago, Stephen Paget advanced his “seed and soil” hypothesis, which suggests that the occurrence of intracerebral metastases is not random, but is secondary to certain tumor cells—“the seed”—having an attraction for the surrounding environment—“the soil”. The hypothesis envisages three principles: first, that the neoplasms are composed of heterogeneous subpopulations of cells, with different characteristics; second, that only a selectively “fit” subpopulation of cells will survive and multiply, invade, and migrate to other locations; and finally, that the colonization depends on tumor cell “seed” and host microenvironment “soil” interactions.[2]
References
- ↑ Andrew B. Lassman & Lisa M. DeAngelis (2003). "Brain metastases". Neurologic clinics. 21 (1): 1–23. PMID 12690643. Unknown parameter
|month=ignored (help) - ↑ Rahmathulla, Gazanfar; Toms, Steven A.; Weil, Robert J. (2012). "The Molecular Biology of Brain Metastasis". Journal of Oncology. 2012: 1–16. doi:10.1155/2012/723541. ISSN 1687-8450.