Essential thrombocytosis laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Lab tests for the diagnosis of Essential thrombocytosis include tests to rule out reactive or secondary causes of thrombocytosis and ET remains a diagnosis of exclusion. The tests include abnormal complete blood count ([[CBC]]), peripheral blood smear, cytogenetic studies including [[Philadelphia chromosome]] or | Lab tests for the diagnosis of Essential thrombocytosis include tests to rule out reactive or secondary causes of thrombocytosis and ET remains a diagnosis of exclusion. The tests include abnormal complete blood count ([[CBC]]), peripheral blood smear, cytogenetic studies including [[Philadelphia chromosome]] or ''BCR-ABL'' assay, and the presence of JAK2 V617F mutations. Bone marrow biopsy is an important test and needed to make a diagnosis of ET<ref name="pmidhttp://dx.doi.org/10.1182/blood-2007-04-083501">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1182/blood-2007-04-083501 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref>as per WHO definition. | ||
==Laboratory findings== | ==Laboratory findings== | ||
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*Complete blood count ([[CBC]]) | *Complete blood count ([[CBC]]) | ||
**Elevated platelet count | **Elevated platelet count | ||
**Leukocytosis, erythrocytosis, and mild anemia may be present | **[[Leukocytosis]], [[erythrocytosis]], and mild anemia may be present | ||
*Peripheral blood smear shows large platelets, megakaryocyte fragments and platelet aggregates<ref>Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.</ref> | *Peripheral blood smear shows large platelets, megakaryocyte fragments and platelet aggregates<ref>Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.</ref> | ||
*To rule out inflammatory disorders | *To rule out inflammatory disorders | ||
**Erythrocyte sedimentation rate (ESR) | **Erythrocyte sedimentation rate ([[ESR]]) | ||
**C-reactive protein (CRP) | **C-reactive protein ([[CRP]]) | ||
**Fibrinogen | **[[Fibrinogen]] | ||
*To rule out Iron deficiency and [[polycythemia vera]] | *To rule out Iron deficiency and [[polycythemia vera]] | ||
**Serum ferritin | **Serum [[ferritin]] | ||
**Hematocrit | **Hematocrit | ||
*To rule out other myeloproliferative neoplasms | *To rule out other myeloproliferative neoplasms | ||
| Line 26: | Line 26: | ||
**Hyperplasia and clustering of megakaryocytes | **Hyperplasia and clustering of megakaryocytes | ||
**Bone marrow stains positive for iron | **Bone marrow stains positive for iron | ||
**Bone marrow reticulin may be increased with no collagen fibrosis | **Bone marrow [[reticulin]] may be increased with no [[collagen]] fibrosis | ||
==References== | ==References== | ||
Revision as of 13:57, 11 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lab tests for the diagnosis of Essential thrombocytosis include tests to rule out reactive or secondary causes of thrombocytosis and ET remains a diagnosis of exclusion. The tests include abnormal complete blood count (CBC), peripheral blood smear, cytogenetic studies including Philadelphia chromosome or BCR-ABL assay, and the presence of JAK2 V617F mutations. Bone marrow biopsy is an important test and needed to make a diagnosis of ET[1]as per WHO definition.
Laboratory findings
Lab tests for the diagnosis of Essential thrombocytosis include the following[2]:
- Complete blood count (CBC)
- Elevated platelet count
- Leukocytosis, erythrocytosis, and mild anemia may be present
- Peripheral blood smear shows large platelets, megakaryocyte fragments and platelet aggregates[3]
- To rule out inflammatory disorders
- Erythrocyte sedimentation rate (ESR)
- C-reactive protein (CRP)
- Fibrinogen
- To rule out Iron deficiency and polycythemia vera
- Serum ferritin
- Hematocrit
- To rule out other myeloproliferative neoplasms
- BCR-ABL or Philadelphia chromosome
- Genetic studies
- JAK2 mutation using PCR
- Bone marrow biopsy
References
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2007-04-083501 Check
|pmid=value (help). - ↑ Essential Thrombocytosis Workup. Medscape. http://emedicine.medscape.com/article/206697-workup#c8. Accessed on November 10th, 2015
- ↑ Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.