Waldenström's macroglobulinemia causes: Difference between revisions
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The most common causes of Waldenström's macroglobulinemia is somatic mutation in MYD88 (90% of patients) and a somatic mutation in CXCR4 (27% of patients).<ref name=wiki> Waldenström's macroglobulinemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Waldenström%27s_macroglobulinemia#cite_note-19 Accessed on November 6, 2015</ref> | ==Overview== | ||
Common causes of Waldenström's macroglobulinemia include genetic, environmental, and autoimmune factors.<ref name=wiki> Waldenström's macroglobulinemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Waldenström%27s_macroglobulinemia#cite_note-19 Accessed on November 6, 2015</ref><ref name=uptodate> Epidemiology, pathogenesis, clinical manifestations and diagnosis of Waldenström macroglobulinemia. UpToDate (2015). http://www.uptodate.com/contents/epidemiology-pathogenesis-clinical-manifestations-and-diagnosis-of-waldenstrom-macroglobulinemia#H3 Accessed on November 6, 2015</ref> | |||
==Causes== | |||
The most common causes of Waldenström's macroglobulinemia is [[somatic mutation]] in MYD88 (90% of patients) and a somatic mutation in [[CXCR4]] (27% of patients).<ref name=wiki> Waldenström's macroglobulinemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Waldenström%27s_macroglobulinemia#cite_note-19 Accessed on November 6, 2015</ref> | |||
Less common causes of Waldenström's macroglobulinemia include: | Less common causes of Waldenström's macroglobulinemia include: | ||
*Chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q | *Chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q | ||
*Environmental factors including exposure to farming, pesticides, wood dust, and organic solvents | *Environmental factors including exposure to farming, pesticides, wood dust, and organic solvents | ||
*Chronic immune stimuation and autoimmune disorders<ref name=uptodate> Epidemiology, pathogenesis, clinical manifestations and diagnosis of Waldenström macroglobulinemia. UpToDate (2015). http://www.uptodate.com/contents/epidemiology-pathogenesis-clinical-manifestations-and-diagnosis-of-waldenstrom-macroglobulinemia#H3 Accessed on November 6, 2015</ref> | *Chronic immune stimuation and [[autoimmune disorders]]<ref name=uptodate> Epidemiology, pathogenesis, clinical manifestations and diagnosis of Waldenström macroglobulinemia. UpToDate (2015). http://www.uptodate.com/contents/epidemiology-pathogenesis-clinical-manifestations-and-diagnosis-of-waldenstrom-macroglobulinemia#H3 Accessed on November 6, 2015</ref> | ||
==References== | ==References== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Common causes of Waldenström's macroglobulinemia include genetic, environmental, and autoimmune factors.[1][2]
Causes
The most common causes of Waldenström's macroglobulinemia is somatic mutation in MYD88 (90% of patients) and a somatic mutation in CXCR4 (27% of patients).[1]
Less common causes of Waldenström's macroglobulinemia include:
- Chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q
- Environmental factors including exposure to farming, pesticides, wood dust, and organic solvents
- Chronic immune stimuation and autoimmune disorders[2]
References
- ↑ 1.0 1.1 Waldenström's macroglobulinemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Waldenström%27s_macroglobulinemia#cite_note-19 Accessed on November 6, 2015
- ↑ 2.0 2.1 Epidemiology, pathogenesis, clinical manifestations and diagnosis of Waldenström macroglobulinemia. UpToDate (2015). http://www.uptodate.com/contents/epidemiology-pathogenesis-clinical-manifestations-and-diagnosis-of-waldenstrom-macroglobulinemia#H3 Accessed on November 6, 2015