Waldenström's macroglobulinemia differential diagnosis: Difference between revisions
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{{CMG}}{{AE}}{{MGS}} | {{CMG}}{{AE}}{{MGS}} | ||
{{Waldenström's macroglobulinemia}} | {{Waldenström's macroglobulinemia}} | ||
===Overview=== | |||
Waldenström's macroglobulinemia must be differentiated from [[Multiple myeloma]], [[Chronic lymphocytic leukemia]]/[[small lymphocytic lymphoma]], [[B-cell prolymphocytic leukemia]], [[Follicular lymphoma]], [[Mantle cell lymphoma]], and Marginal zone lymphoma. <ref name="UTD"></ref> | |||
===Differentiating Waldenström's macroglobulinemia from other B cell lymphoid neoplasms=== | |||
Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including: | Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including: | ||
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::*Most common cytogenetic abnormalities are loss of 7q (19%) along with +3q (19%) and +5q (10% ) | ::*Most common cytogenetic abnormalities are loss of 7q (19%) along with +3q (19%) and +5q (10% ) | ||
=References | =References= | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 20:05, 12 November 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Overview
Waldenström's macroglobulinemia must be differentiated from Multiple myeloma, Chronic lymphocytic leukemia/small lymphocytic lymphoma, B-cell prolymphocytic leukemia, Follicular lymphoma, Mantle cell lymphoma, and Marginal zone lymphoma. [1]
Differentiating Waldenström's macroglobulinemia from other B cell lymphoid neoplasms
Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:
- Always express CD5, usually CD23 positive[1]
- Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7)[1]
- Express CD138, CD38, CD79a, and VS38c and CD56(70%)[1]
- Presence of Plasmacytic cell infiltration of bone marrow, osteolytic lesions and renal insufficiency[2]
- Translocation involving chromosome 11 (t 11;14)
- Marginal zone lymphoma:
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015
- ↑ 2.0 2.1 2.2 2.3 Sahin I, Leblebjian H, Treon SP, Ghobrial IM (2014). "Waldenström macroglobulinemia: from biology to treatment". Expert Rev Hematol. 7 (1): 157–68. doi:10.1586/17474086.2014.871494. PMID 24405328.