Ovarian germ cell tumor pathophysiology: Difference between revisions
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Solid (55%), glandular (17%), and papillary (11%) are the most common primary patterns (predominant architectural pattern occupying at least 50%). Other less common primary patterns included nested (3%), micropapillary (2%), anastomosing glandular (1%), sieve-like glandular (<1%), pseudopapillary (<1%), and blastocyst-like (<1%).<ref name="pmid24503753">{{Cite journal | pmid = 24503753| year = 2014| author1 = Kao| first1 = C. S.| title = Testicular Embryonal Carcinoma: A Morphologic Study of 180 Cases Highlighting Unusual and Unemphasized Aspects| journal = The American Journal of Surgical Pathology| pages = 1| last2 = Ulbright| first2 = T. M.| last3 = Young| first3 = R. H.| last4 = Idrees| first4 = M. T.| doi = 10.1097/PAS.0000000000000171 | volume=38 | issue=5}}</ref> | Solid (55%), glandular (17%), and papillary (11%) are the most common primary patterns (predominant architectural pattern occupying at least 50%). Other less common primary patterns included nested (3%), micropapillary (2%), anastomosing glandular (1%), sieve-like glandular (<1%), pseudopapillary (<1%), and blastocyst-like (<1%).<ref name="pmid24503753">{{Cite journal | pmid = 24503753| year = 2014| author1 = Kao| first1 = C. S.| title = Testicular Embryonal Carcinoma: A Morphologic Study of 180 Cases Highlighting Unusual and Unemphasized Aspects| journal = The American Journal of Surgical Pathology| pages = 1| last2 = Ulbright| first2 = T. M.| last3 = Young| first3 = R. H.| last4 = Idrees| first4 = M. T.| doi = 10.1097/PAS.0000000000000171 | volume=38 | issue=5}}</ref> | ||
==Gross Patholgy== | |||
{| {{table}} | |||
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|''' Ovarian germ cell tumor subtype'''}} | |||
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Features on Gross Pathology'''}} | |||
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| Dysgerminoma|| | |||
* Serum lactate dehydrogenase (LDH) | |||
* Human chorionic gonadotropin (HCG) | |||
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|Endodermal sinus tumor or yolk sac tumors|| | |||
* Alpha-fetoprotein (AFP) | |||
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| Embryonal Carcinoma|| | |||
* HCG, AFP | |||
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| Teratoma|| | |||
* Rarely produce tumor markers- AFP and CA-125 | |||
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| Choriocarcinoma|| | |||
* HCG | |||
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|} | |||
Revision as of 16:43, 13 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Dysgerminomas
- On gross examination,
- dysgerminomas present with a smooth, bosselated (knobby) external surface, and is soft, fleshy and either cream-coloured, gray, pink or tan when cut.
- Microscopic examination
- typically reveals uniform cells that resemble primordial germ cells. Typically, thestroma contains lymphocytes and about 20% of patients have sarcoid-like granulomas.
EST can have a multitude of morphologic patterns including: reticular, endodermal sinus-like, microcystic, papillary, solid, glandular, alveolar, polyvesicular vitelline, enteric and hepatoid. Schiller-Duval bodies on histology are pathognomonic and seen in the context of the endodermal sinus-like pattern.
The gross examination usually shows a two to three centimetre pale grey, poorly defined tumour with associated haemorrhage and necrosis.[1] The microscopic features include: indistinct cell borders, mitoses, a variable architecture (tubulopapillary, glandular, solid, embryoid bodies - ball of cells surrounded by empty space on three sides), nuclear overlap, and necrosis. Solid (55%), glandular (17%), and papillary (11%) are the most common primary patterns (predominant architectural pattern occupying at least 50%). Other less common primary patterns included nested (3%), micropapillary (2%), anastomosing glandular (1%), sieve-like glandular (<1%), pseudopapillary (<1%), and blastocyst-like (<1%).[2]
Gross Patholgy
| Ovarian germ cell tumor subtype | Features on Gross Pathology |
| Dysgerminoma |
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| Endodermal sinus tumor or yolk sac tumors |
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| Embryonal Carcinoma |
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| Teratoma |
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| Choriocarcinoma |
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References
- ↑ Abbas, Fausto, Mitchell (2010). Basic Pathology. Elsevier. pp. 696–697. ISBN 978-81-312-1036-9.
- ↑ Kao, C. S.; Ulbright, T. M.; Young, R. H.; Idrees, M. T. (2014). "Testicular Embryonal Carcinoma: A Morphologic Study of 180 Cases Highlighting Unusual and Unemphasized Aspects". The American Journal of Surgical Pathology. 38 (5): 1. doi:10.1097/PAS.0000000000000171. PMID 24503753.