Hepatocellular adenoma pathophysiology: Difference between revisions
Jump to navigation
Jump to search
Nawal Muazam (talk | contribs) No edit summary |
Nawal Muazam (talk | contribs) No edit summary |
||
| Line 11: | Line 11: | ||
The pathogenesis of hepatocellular adenoma usually involves the Wnt signalling pathway. | The pathogenesis of hepatocellular adenoma usually involves the Wnt signalling pathway. | ||
==Gross Pathology== | ==Gross Pathology== | ||
On gross pathology, well circumscribed, nonlobulated, smooth and soft, white to yellow to brown lesions are findings of a solitary hepatocellular adenoma.<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref><ref name="pmid11452062">{{cite journal| author=Grazioli L, Federle MP, Brancatelli G, Ichikawa T, Olivetti L, Blachar A| title=Hepatic adenomas: imaging and pathologic findings. | journal=Radiographics | year= 2001 | volume= 21 | issue= 4 | pages= 877-92; discussion 892-4 | pmid=11452062 | doi=10.1148/radiographics.21.4.g01jl04877 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11452062 }} </ref> | On gross pathology, well circumscribed, nonlobulated, smooth and soft, and white to yellow to brown lesions are findings of a solitary hepatocellular adenoma.<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref><ref name="pmid11452062">{{cite journal| author=Grazioli L, Federle MP, Brancatelli G, Ichikawa T, Olivetti L, Blachar A| title=Hepatic adenomas: imaging and pathologic findings. | journal=Radiographics | year= 2001 | volume= 21 | issue= 4 | pages= 877-92; discussion 892-4 | pmid=11452062 | doi=10.1148/radiographics.21.4.g01jl04877 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11452062 }} </ref> | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
On microscopic histopathological analysis, cords of hepatocytes that have a high glycogen and fat content, lack of normal hepatic parenchymal architecture and an absence of portal tracts and hepatic veins are characteristic findings of hepatocellular adenoma.<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref> | On microscopic histopathological analysis, cords of hepatocytes that have a high glycogen and fat content, lack of normal hepatic parenchymal architecture, and an absence of portal tracts and hepatic veins are characteristic findings of hepatocellular adenoma.<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref> | ||
<Gallery> | <Gallery> | ||
Image: | Image: | ||
| Line 20: | Line 19: | ||
Image: | Image: | ||
Hepatocellular adenoma high magnification.jpg|<sub>High magnification micrograph of a hepatic adenoma. H&E stain.<ref name=b>Hepatic adenoma. Librepathology (2015). http://librepathology.org/wiki/index.php/File:Hepatic_adenoma_high_mag.jpg Accessed on November 7, 2015</ref></sub> | Hepatocellular adenoma high magnification.jpg|<sub>High magnification micrograph of a hepatic adenoma. H&E stain.<ref name=b>Hepatic adenoma. Librepathology (2015). http://librepathology.org/wiki/index.php/File:Hepatic_adenoma_high_mag.jpg Accessed on November 7, 2015</ref></sub> | ||
</Gallery> | </Gallery> | ||
Revision as of 19:21, 13 November 2015
|
Hepatocellular adenoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Hepatocellular adenoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of Hepatocellular adenoma pathophysiology |
|
Risk calculators and risk factors for Hepatocellular adenoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
On gross pathology, well circumscribed, nonlobulated, smooth and soft, and white to yellow to brown lesions are findings of a solitary hepatocellular adenoma.[1][2] On microscopic histopathological analysis, cords of hepatocytes that have a high glycogen and fat content, lack of normal hepatic parenchymal architecture, and an absence of portal tracts and hepatic veins are characteristic findings of hepatocellular adenoma.[1]
Pathophysiology
Pathogenesis
Genetics
The pathogenesis of hepatocellular adenoma usually involves the Wnt signalling pathway.
Gross Pathology
On gross pathology, well circumscribed, nonlobulated, smooth and soft, and white to yellow to brown lesions are findings of a solitary hepatocellular adenoma.[1][2]
Microscopic Pathology
On microscopic histopathological analysis, cords of hepatocytes that have a high glycogen and fat content, lack of normal hepatic parenchymal architecture, and an absence of portal tracts and hepatic veins are characteristic findings of hepatocellular adenoma.[1]
-
![Low magnification micrograph of a hepatic adenoma. H&E stain.[3]](/images/9/90/Hepatic_adenoma_low_magnification.jpg)
Low magnification micrograph of a hepatic adenoma. H&E stain.[3] -
![High magnification micrograph of a hepatic adenoma. H&E stain.[4]](/images/4/42/Hepatocellular_adenoma_high_magnification.jpg)
High magnification micrograph of a hepatic adenoma. H&E stain.[4]
![Low magnification micrograph of a hepatic adenoma. H&E stain.[3]](/index.php/File:Hepatic_adenoma_low_magnification.jpg)
![High magnification micrograph of a hepatic adenoma. H&E stain.[4]](/index.php/File:Hepatocellular_adenoma_high_magnification.jpg)
References
- ↑ 1.0 1.1 1.2 1.3 Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
- ↑ 2.0 2.1 Grazioli L, Federle MP, Brancatelli G, Ichikawa T, Olivetti L, Blachar A (2001). "Hepatic adenomas: imaging and pathologic findings". Radiographics. 21 (4): 877–92, discussion 892-4. doi:10.1148/radiographics.21.4.g01jl04877. PMID 11452062.
- ↑ Hepatic adenoma. Librepathology (2015). http://librepathology.org/wiki/index.php/File:Hepatic_adenoma_low_mag.jpg Accessed on November 3, 2015
- ↑ Hepatic adenoma. Librepathology (2015). http://librepathology.org/wiki/index.php/File:Hepatic_adenoma_high_mag.jpg Accessed on November 7, 2015
