Myxoma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
Cardiac myxoma contains undifferentiated mesenchymal cells, which potentially differentiate into many tissues such as blood vessels, glandular structures, bones, and source of extramedullary hematopoiesis. | Cardiac myxoma contains undifferentiated mesenchymal cells, which potentially differentiate into many [[tissues]] such as [[blood vessels]], [[glandular]] structures, [[bones]], and source of extramedullary [[hematopoiesis]]. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Revision as of 20:26, 13 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]Ahmad Al Maradni, M.D. [3]Maria Fernanda Villarreal, M.D. [4]
Overview
Cardiac myxoma contains undifferentiated mesenchymal cells, which potentially differentiate into many tissues such as blood vessels, glandular structures, bones, and source of extramedullary hematopoiesis.
Pathophysiology
Cardiac myxoma arises from myxoid collagenous stroma, which is composed of mesenchymal cells that are normally involved in the supportive structure of the tissue. Myxomas are usually located in the endocardium of the atrial septum. Some symptoms of myxoma may be associated with the release of interleukin 6 (IL-6) by the myxoma.[1][2]
Gross Pathology
On gross pathology, external appearance, consistency size and weight are extremely variable findings of cardiac myxoma. Large cardiac myxomas are usually located in fossa ovalis and tend to be sessile or pedunculated. Tumor consistency depends on the quantity and distribution of fibrous tissue and calcification. A macroscopic gelatinous, irregular surface that fills the left atrium is a characteristic finding of myxoma.
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A gelatinous tumor is attached by a narrow pedicle to the atrial septum. The myxoma has an irregular surface and nearly fills the left atrium. -
Left Atrial Myxoma
Microscopic Pathology
On microscopic histopathological analysis, Gamna-Bodies consist of fibrosis and deposition of iron pigments are characteristic findings of myxoma. Myxoma cells can be elongated, fusiform or stellate. They contain modest amounts of eosinophilic cytoplasm and have oval nuclei.
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Cardiac Myxoma: Gamna Bodies: A peculiar form of fibrosis with deposition of iron pigment, identical to that seen in the spleens of patients with sickle cell anemia, is not uncommon in myxoma.
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Cardiac Myxoma Common features at the interface with the atrial septum include lymphoid aggregates, smooth muscle bundles, and thick walled vessels which angiographically may look like neovascularization. -
Cardiac Myxoma The extramedullary hematopoiesis seen here is present in about 7 percent of cardiac myxomas.
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Cardiac Myxoma Glandular structures are seen in less than 5 percent of cases. In this example, they were limited to the base of the myxoma
References
- ↑ Seino Y, Ikeda U, Shimada K. (1993). "Increased expression of interleukin 6 mRNA in cardiac myxomas". Br Heart J. 69 (6): 565–7. PMID 8343326.
- ↑ Jourdan M, Bataille R, Seguin J, Zhang XG, Chaptal PA, Klein B (1990). "Constitutive production of interleukin-6 and immunologic features in cardiac myxomas". Arthritis Rheum. 33 (3): 398–402. PMID 1690543.