Anaplastic large cell lymphoma natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
The ALK-positive anaplastic large cell lymphoma is associated with the most favorable prognosis. | The ALK-positive anaplastic large cell lymphoma is associated with the most favorable prognosis. ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 70-80%. ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 30-40%. | ||
==Prognosis== | ==Prognosis== | ||
* Those with ALK positivity have a better [[prognosis]] | * Those with ALK positivity have a better [[prognosis]] |
Revision as of 15:09, 16 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The ALK-positive anaplastic large cell lymphoma is associated with the most favorable prognosis. ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 70-80%. ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 30-40%.
Prognosis
- Those with ALK positivity have a better prognosis
- ALK-negative anaplastic large cell lymphomas represent other T-cell lymphomas in a final common pathway of disease progression
- Overall better prognosis than other "Aggressive Lymphomas"
- ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 70-80%
- ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 30-40%
- The International Prognostic Iindex (IPI) is used to estimate the prognosis of patients.[1] The IPI takes into account 5 variables:
- Patient's age (>60 years)
- Elevated serum lactate dehydrogenase (LDH)
- Eastern Cooperative Oncology Group (ECOG) performance status
- Ann Arbor clinical stage III or IV
- Number of involved extra nodal sites > 1
- If any of this criteria is met, one point is awarded for the IPI. The interpretation of the total score is as follows:
- 0 to 1: Low risk
- 2: Low-intermediate risk
- 3: High-intermediate risk
- 4 to 5: High risk
- According to the International Peripheral T cell Lymphoma Project, the estimated 5-years survival for each of the IPI stages are as follows:[2]
- Low risk (IPI 0-1): 90%
- Low-intermediate risk (IPI 2): 68%
- High-intermediate risk (IPI 3): 23%
- High risk (IPI 4-5): 33%
- However, recently, the International peripheral T-cell lymphoma Project score (IPTCLP) has demonstrated to be the most accurate score to predict overall survival in patients.[3] This score includes:
- Age
- Eastern Cooperative Oncology Group (ECOG) performance status
- Platelet count
References
- ↑ "International Prognostic Index for non-Hodgkin lymphoma".
- ↑ "ALK− anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project".
- ↑ "Comparison of four prognostic scores in peripheral T-cell lymphoma".