Ovarian germ cell tumor pathophysiology: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
Line 2: Line 2:
{{Ovarian germ cell tumor}}
{{Ovarian germ cell tumor}}
{{CMG}}{{AE}} {{MD}}
{{CMG}}{{AE}} {{MD}}
Dysgerminomas
* On gross examination,
* dysgerminomas present with a smooth, bosselated (knobby) external surface, and is soft, fleshy and either cream-coloured, gray, pink or tan when cut.
* Microscopic examination
* typically reveals uniform cells that resemble primordial germ cells. Typically, thestroma contains lymphocytes and about 20% of patients have sarcoid-like granulomas.
EST can have a multitude of morphologic patterns including: reticular, endodermal sinus-like, microcystic, papillary, solid, glandular, alveolar, polyvesicular vitelline, enteric and hepatoid.
[[Schiller-Duval bodies]] on [[histology]] are [[pathognomonic]] and seen in the context of the endodermal sinus-like pattern.
The [[gross examination]] usually shows a two to three centimetre pale grey, poorly defined tumour with associated [[haemorrhage]] and [[necrosis]].<ref name=Robbins>{{cite book|last=Abbas, Fausto, Mitchell|title=Basic Pathology|year=2010|publisher=Elsevier|isbn=978-81-312-1036-9|pages=696–697}}</ref>
The microscopic features include: indistinct cell borders, mitoses, a variable architecture (tubulopapillary, glandular, solid, embryoid bodies - ball of cells surrounded by empty space on three sides), nuclear overlap, and necrosis.
Solid (55%), glandular (17%), and papillary (11%) are the most common primary patterns (predominant architectural pattern occupying at least 50%). Other less common primary patterns included nested (3%), micropapillary (2%), anastomosing glandular (1%), sieve-like glandular (<1%), pseudopapillary (<1%), and blastocyst-like (<1%).<ref name="pmid24503753">{{Cite journal | pmid = 24503753| year = 2014| author1 = Kao| first1 = C. S.| title = Testicular Embryonal Carcinoma: A Morphologic Study of 180 Cases Highlighting Unusual and Unemphasized Aspects| journal = The American Journal of Surgical Pathology| pages = 1| last2 = Ulbright| first2 = T. M.| last3 = Young| first3 = R. H.| last4 = Idrees| first4 = M. T.| doi = 10.1097/PAS.0000000000000171 | volume=38 | issue=5}}</ref>


==Gross Patholgy==
==Gross Patholgy==

Revision as of 18:31, 16 November 2015

Ovarian germ cell tumor Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Screening

Differentiating Ovarian germ cell tumor from other Diseases

Natural History, Complications and Prognosis

Diagnosis

Staging

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Surgery

Chemotherapy

Radiotherapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ovarian germ cell tumor pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ovarian germ cell tumor pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ovarian germ cell tumor pathophysiology

CDC on Ovarian germ cell tumor pathophysiology

Ovarian germ cell tumor pathophysiology in the news

Blogs on Ovarian germ cell tumor pathophysiology

Directions to Hospitals Treating Ovarian germ cell tumor

Risk calculators and risk factors for Ovarian germ cell tumor pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Gross Patholgy

Ovarian germ cell tumor subtype Features on Gross Pathology
Dysgerminoma
  • External surface is smooth and bosselated (knobby)
  • Cut surface it is soft, fleshy and either cream-coloured, gray, pink or tan
Endodermal sinus tumor or yolk sac tumors
  • External surface is smooth and glistening
  • Cut surface is cystic with hemorrhage and necrosis
Embryonal Carcinoma
Teratoma

Teratoma-mature

  • Solid or cystic
  • Cystic content may contain greasy material composed of keratin, hair and teeth
  • Teeth may be found in Rokitansky’s protuberance - a well-defined, nipple-like structure covered with hair

Teratoma-immature

  • Bulky, solid or cystic with necrosis, hemorrhage
Choriocarcinoma
  • Hemorrhagic, soft, tan with necrosis

http://www.pathologyoutlines.com/topic/ovarytumorchorio.html

Microscopic Pathology

Ovarian germ cell tumor subtype Features on Histopathological Microscopic Analysis Image
Dysgerminomas
  • Uniform cells that resemble primordial germ cells
  • The stroma contains lymphocytes and about 20% of patients have sarcoid-like granulomas
Micrograph a seminoma, a tumor that is histologically indistinguishable from dysgerminoma.
Endodermal sinus tumor or yolk sac tumors
  • Schiller-Duval bodies - key feature
Micrograph showing the yolk sac component of a mixed germ cell tumor.


Embryonal carcinoma

Main features:[1]

  • Nuclear atypia
  • Nucleoli prominent
  • Necrosis common
  • Nuclei overlap

Other features:

  • Variable architecture:
  • Tubulopapillary
  • Glandular
  • Solid
  • Embryoid bodies - ball of cells in surrounded by empty space on three sides
  • Mitoses common
Embryonal carcinoma
Teratoma Mature teratoma
  • The sections show ovarian parenchyma with a lesion consisting of benign dermal, gastrointestinal and neural elements
  • The neural elements show focal degenerative changes with macrophages, and giant cells
  • Siderophages are present
Teratoma
Choriocarcinoma

References

  1. ↑ 1.0 1.1 Abbas, Fausto, Mitchell (2010). Basic Pathology. Elsevier. pp. 696–697. ISBN 978-81-312-1036-9.

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Ovarian_germ_cell_tumor_pathophysiology&oldid=1187504"