Waldenström's macroglobulinemia differential diagnosis: Difference between revisions
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:*Express CD138, CD38, CD79a, and VS38c and CD56(70%)<ref name="UTD"></ref> | :*Express CD138, CD38, CD79a, and VS38c and CD56(70%)<ref name="UTD"></ref> | ||
:*Presence of Plasmacytic cell infiltration of bone marrow, osteolytic lesions and [[renal insufficiency]]<ref name="pubM"></ref> | :*Presence of Plasmacytic cell infiltration of bone marrow, osteolytic lesions and [[renal insufficiency]]<ref name="pubM"></ref> | ||
:*Translocation involving chromosome 11 ( | :*Translocation involving chromosome 11 (t11;14) | ||
*[[Mantle cell lymphoma]]: | *[[Mantle cell lymphoma]]: | ||
Revision as of 18:49, 16 November 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
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Waldenström's macroglobulinemia Microchapters |
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Diagnosis |
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Treatment |
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Overview
Waldenström's macroglobulinemia must be differentiated from Multiple myeloma, Chronic lymphocytic leukemia/small lymphocytic lymphoma, B-cell prolymphocytic leukemia, Follicular lymphoma, Mantle cell lymphoma, and Marginal zone lymphoma. [1]
Differentiating Waldenström's macroglobulinemia from other B cell lymphoid neoplasms
Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:
- Always express CD5, usually CD23 positive[1]
- Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7)[1]
- Express CD138, CD38, CD79a, and VS38c and CD56(70%)[1]
- Presence of Plasmacytic cell infiltration of bone marrow, osteolytic lesions and renal insufficiency[2]
- Translocation involving chromosome 11 (t11;14)
- Marginal zone lymphoma:
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015
- ↑ 2.0 2.1 2.2 2.3 Sahin I, Leblebjian H, Treon SP, Ghobrial IM (2014). "Waldenström macroglobulinemia: from biology to treatment". Expert Rev Hematol. 7 (1): 157–68. doi:10.1586/17474086.2014.871494. PMID 24405328.