Waldenström's macroglobulinemia laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Elevated Beta-2-microglobulin and abnormal coagulation studies are diagnostic of Waldenström's macroglobulinemia. <ref name="LAB">Waldenström's macroglobulinemia. Medscape (2015)http://emedicine.medscape.com/article/207097-workup#c7 Accessed on November 10, 2015</ref> | Elevated Beta-2-microglobulin and abnormal coagulation studies are diagnostic of Waldenström's macroglobulinemia. <ref name="LAB">Waldenström's macroglobulinemia. Medscape (2015)http://emedicine.medscape.com/article/207097-workup#c7 Accessed on November 10, 2015</ref> | ||
__NOTOC__ | |||
{{Waldenström's macroglobulinemia}} | |||
{{CMG}}{{AE}}{{MGS}} | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
===Complete blood count=== | |||
*Normocytic normochromic anemia - presents in 80% of patients<ref name="LAB">Waldenström's macroglobulinemia. Medscape (2015)http://emedicine.medscape.com/article/207097-workup#c7 Accessed on November 10, 2015</ref> | *[[Normocytic normochromic anemia]] - presents in 80% of patients<ref name="LAB">Waldenström's macroglobulinemia. Medscape (2015)http://emedicine.medscape.com/article/207097-workup#c7 Accessed on November 10, 2015</ref> | ||
*Leukopenia | *[[Leukopenia]] | ||
*Thrombocytopenia - presents in 50% of patients with bleeding diathesis | *[[Thrombocytopenia]] - presents in 50% of patients with bleeding diathesis | ||
===Peripheral smear=== | |||
*Plasmacytoid lymphocytes | *Plasmacytoid lymphocytes | ||
*Normocytic normochromic red blood cells | *Normocytic normochromic red blood cells | ||
*Rouleaux formation | *[[Rouleaux]] formation | ||
===Chemistry lab tests=== | |||
*Elevated Beta-2-microglobulin in proportion to tumor mass | *Elevated [[Beta-2-microglobulin]] in proportion to tumor mass | ||
*Elevated Lactate dehydrogenase | *Elevated [[Lactate dehydrogenase]] | ||
*Elevated Creatinine | *Elevated [[Creatinine]] | ||
*Electrolyte abnormalities: | *Electrolyte abnormalities: | ||
:*Hypercalcemia(4%) | :*Hypercalcemia(4%) | ||
*Elevated Erythrocyte Sedimentation Rate and uric acid | *Elevated [[Erythrocyte Sedimentation Rate]] and [[uric acid]] | ||
*Total protein levels | *Total protein levels | ||
*Albumin-to-globulin ratio | *[[Albumin-to-globulin ratio]] | ||
*Rheumatoid factor, cryoglobulins, direct antiglobulin test and cold agglutinin titre results can be positive. | *[[Rheumatoid factor]], [[cryoglobulins]], direct antiglobulin test and cold agglutinin titre results can be positive. | ||
*Coaglulation studies can be abnormal with elevated prothrombin time, activated partial thromboplastin time, and thrombin time. | *Coaglulation studies can be abnormal with elevated [[prothrombin time]], [[activated partial thromboplastin time]], and [[thrombin time]]. | ||
===Plasma viscosity=== | |||
*Plasma viscosity should be measured in patients presenting with [[hyperviscosity syndrome]] whenever the monoclonal IgM protein spike is >4 g/dL.<ref name="LR">Waldenström's macroglobulinemia. UpToDate (2015)http://www.uptodate.com/contents/epidemiology-pathogenesis-clinical-manifestations-and-diagnosis-of-waldenstrom-macroglobulinemia?source=machineLearning&search=Waldenström%27s+macroglobulinemia&selectedTitle=1%7E80§ionRank=3&anchor=H29#H18 Accessed on November 10, 2015</ref> | *Plasma viscosity should be measured in patients presenting with [[hyperviscosity syndrome]] whenever the monoclonal IgM protein spike is >4 g/dL.<ref name="LR">Waldenström's macroglobulinemia. UpToDate (2015)http://www.uptodate.com/contents/epidemiology-pathogenesis-clinical-manifestations-and-diagnosis-of-waldenstrom-macroglobulinemia?source=machineLearning&search=Waldenström%27s+macroglobulinemia&selectedTitle=1%7E80§ionRank=3&anchor=H29#H18 Accessed on November 10, 2015</ref> | ||
*The normal Plasma viscosity is 1.8 centipoise. | *The normal Plasma viscosity is 1.8 centipoise. | ||
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==References== | |||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:28, 17 November 2015
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Waldenström's macroglobulinemia Microchapters |
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Waldenström's macroglobulinemia laboratory findings On the Web |
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American Roentgen Ray Society Images of Waldenström's macroglobulinemia laboratory findings |
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Waldenström's macroglobulinemia laboratory findings in the news |
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Blogs on Waldenström's macroglobulinemia laboratory findings |
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Directions to Hospitals Treating Waldenström's macroglobulinemia |
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Risk calculators and risk factors for Waldenström's macroglobulinemia laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Elevated Beta-2-microglobulin and abnormal coagulation studies are diagnostic of Waldenström's macroglobulinemia. [1]
|
Waldenström's macroglobulinemia Microchapters |
|
Differentiating Waldenström's macroglobulinemia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Waldenström's macroglobulinemia laboratory findings On the Web |
|
American Roentgen Ray Society Images of Waldenström's macroglobulinemia laboratory findings |
|
Waldenström's macroglobulinemia laboratory findings in the news |
|
Blogs on Waldenström's macroglobulinemia laboratory findings |
|
Directions to Hospitals Treating Waldenström's macroglobulinemia |
|
Risk calculators and risk factors for Waldenström's macroglobulinemia laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [4]
Laboratory Findings
Complete blood count
- Normocytic normochromic anemia - presents in 80% of patients[1]
- Leukopenia
- Thrombocytopenia - presents in 50% of patients with bleeding diathesis
Peripheral smear
- Plasmacytoid lymphocytes
- Normocytic normochromic red blood cells
- Rouleaux formation
Chemistry lab tests
- Elevated Beta-2-microglobulin in proportion to tumor mass
- Elevated Lactate dehydrogenase
- Elevated Creatinine
- Electrolyte abnormalities:
- Hypercalcemia(4%)
- Elevated Erythrocyte Sedimentation Rate and uric acid
- Total protein levels
- Albumin-to-globulin ratio
- Rheumatoid factor, cryoglobulins, direct antiglobulin test and cold agglutinin titre results can be positive.
- Coaglulation studies can be abnormal with elevated prothrombin time, activated partial thromboplastin time, and thrombin time.
Plasma viscosity
- Plasma viscosity should be measured in patients presenting with hyperviscosity syndrome whenever the monoclonal IgM protein spike is >4 g/dL.[2]
- The normal Plasma viscosity is 1.8 centipoise.
- Patients start presenting with hyperviscosity symptoms when viscosity >4 centipoise.
References
- ↑ 1.0 1.1 Waldenström's macroglobulinemia. Medscape (2015)http://emedicine.medscape.com/article/207097-workup#c7 Accessed on November 10, 2015
- ↑ Waldenström's macroglobulinemia. UpToDate (2015)http://www.uptodate.com/contents/epidemiology-pathogenesis-clinical-manifestations-and-diagnosis-of-waldenstrom-macroglobulinemia?source=machineLearning&search=Waldenström%27s+macroglobulinemia&selectedTitle=1%7E80§ionRank=3&anchor=H29#H18 Accessed on November 10, 2015