Altered mental status causes: Difference between revisions

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*[[Acidosis]]
*[[Acidosis]]
*[[Adrenal insufficiency|Acute adrenal insufficiency]]
*[[Acute altitude sickness]]
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*[[Delirium|Acute confusional state]]
*[[Delirium|Acute confusional state]]
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*[[Anterior cerebral artery|Bilateral anterior cerebral artery occlusion]]
*[[Anterior cerebral artery|Bilateral anterior cerebral artery occlusion]]
*[[Bilateral internal carotid occlusion]]  
*[[Internal carotid artery|Bilateral internal carotid occlusion]]  
*[[Basal ganglia diseases]]  
*[[Basal ganglia diseases]]  
*[[Bipolar disorder]]  
*[[Bipolar disorder]]  

Revision as of 16:09, 19 November 2015

Altered mental status Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Altered mental status from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

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Medical Therapy

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Cost-Effectiveness of Therapy

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2] Kiran Singh, M.D. [3]

Overview

Altered mental status has varying time courses and degrees of severity. Acute changes in mental status are usually secondary to delirium, stupor, and coma, which are forms of acute brain dysfunction. These changes occur over a period of hours or days and are usually precipitated by an underlying medical illness that is potentially life threatening. Chronic alterations in mental status (e.g. dementia) occur over a period of months and years and are less likely to be precipitated by a life-threatening illness. For these reasons, acute changes in mental status will be the focus of this review. Altered mental status is rarely caused by psychiatric illnesses such as depression or schizophrenia, and in elder patients, these should be diagnoses of exclusion. Acute brain dysfunction (delirium, stupor, and coma) and their underlying etiology should be ruled out prior to considering any psychiatric diagnoses, especially in patients without a previous history of psychiatric illness.

Causes

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular Malignant hypertension, Heart failure, Myocardial infarction, Congestive heart failure, Ventricular arrhythmia
Chemical/Poisoning Withdrawal states from ethanol, benzodiazepines,Water hemlock poisoning, Toxic mushrooms -- Monomethylhydrazine ,Toluene, Texas Mescalbean poisoning,Poison hemlock, Organic solvent, Methanol , Marijuana, Lead, Jimson weed, Hyperbaric sickness, Hydrogen sulfide , Heroin ,Hallucinogens, Ethylene glycol, Ethanol, Daphne poisoning, Cyanide, Carbon tetrachloride, Carbon monoxide toxicity, Alcohol withdrawal, Thallium Sulfate poisoning,Phencyclidine poisoning, Nickel, Carbonyl poisoning
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Muscle relaxants, Serotonin syndrome, Quinolones, Lithium, Drug withdrawal, Drug overdose,Cabergoline, Antihistamines, Antidepressants: for instance sedating tricyclic antidepressants, Analgesics: mostly prescribed or illicit opiates such as oxycontin, Antiepileptics such as phenytoin, carbamazepine, gabapentin, Antihistamines: diphenhydramine and doxylamine, Antipsychotics: thioridazine, quetiapine, olanzapine, risperidone, and ziprasidone but not haloperidol, HIV medications for example, efavirenz, Antihypertensive medications like amlodipine, Hypnotics like zopiclone, or the benzodiazepine such as diazepam or nitrazepam and the barbiturate, such as amobarbital or secobarbital, Benzodiazepine receptor agonists: Eszopiclone, Zolpidem, Zaleplon, Dopamine agonists used in the treatment of parkinson's disease e.g. pergolide, ropinirole and pramipexole, Antiepileptics such as phenytoin, carbamazepine, gabapentin
Ear Nose Throat No underlying causes
Endocrine Pituitary apoplexy, Phaeochromocytoma, Hypothyroidism, Hypopituitarism, Hypoglycemia, Hyperthyroidism,Hyperosmolar non-ketotic diabetic coma, Hyperglycemia, Hyperthyroidism, Elevated or depressed pituitary function ,Elevated or depressed adrenal function, Diabetic ketoacidosis, Diabetic hypoglycemia, Cushing syndrome, Adrenal cortex insufficiency , Thyrotoxicosis, Myxedema coma, Pituitary apoplexy
Environmental Hypothermia, Hyperthermia, Heat stroke, Electric shock, Decompression sickness, Acute Altitude sickness
Gastroenterologic Elevated or depressed pancreas function, Chronic Liver failure, Acute Liver failure, Mesenteric ischemia, Appendicitis, Acute diverticulitis, Constipation
Genetic No underlying causes
Hematologic Thrombocytosis, Polycythemia, Leukemic blast cell crisis, Hypereosinophilia
Iatrogenic Postoperative stress
Infectious Disease Viral hemorrhagic fever, Vancomycin resistant enterococcal bacteremia, Urinary tract infection, Typhoid fever, systemic inflammatory response syndrome, Systemic infection, Wound#infectionSurgical wound infection, Subdural empyema, Sleeping sickness (West African), Sleeping sickness (East African), Sepsis, Rickettsiae, Rabies , Pyelonephritis, acute, Plague , Neurocysticercosis,Malaria, Intraspinal abscess / granuloma, Intracranial abscess / granuloma, Gangrene , Chest infection, Cerebral malaria,Brain or epidural abscess, Brain infection, Infectious mononucleosis (glandular fever), Lyme disease
Musculoskeletal/Orthopedic Fibromyalgia
Neurologic Venous sinus thrombosis, Raised intracranial pressure, Postictal state, Nonconvulsive status epilepticus,Meningoencephalitis, Meningitis, Intracranial bleeding, Hypertensive encephalopathy, Epileptic seizures, Epidural haemorrhage,Encephalitis, Encephalitis, Cerebrovascular accident, Cerebral oedema, Cerebral infarction, Brain tumor, Brain abscess, Subdural hematoma, Epidural hematoma, Subarachnoid hemorrhage, Brain tumor, Neurosyphilis, Sleep apnea, Brain edema, Cerebral hypoxia, Hydrocephalus
Nutritional/Metabolic Wilson's disease, Wernicke's encephalopathy, Vitamin B12 deficiency, Thiamine (Vitamin B1) deficiency, Niacin deficiencies, Folate deficiency, Acute intermittent porphyria, Starvation
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric Schizoaffective disorder , Advanced sleep phase disorder, Delayed sleep phase syndrome
Pulmonary Respiratory failure, Hypoxemia, Hypercarbia
Renal/Electrolyte Hypophosphatemia, hypoosmolar states, Hyponatremia, Hypocalcemia, Hyperosmolar states, Hypernatremia,

Hypermagnesemia, Hypercalcemia, Hypomagnesemia, Hyperphosphatemia, Chronic Renal failure, Acute Renal failure, Uremia, Dehydration

Rheumatology/Immunology/Allergy Vasculitis
Sexual No underlying causes
Trauma Trauma, Skull fracture, Head injury
Urologic Urinary Track Infection
Miscellaneous Coproporphyria, Burns, Chronic fatigue syndrome

Causes in Alphabetical Order

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References

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