Sandbox Maliha: Difference between revisions

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Maliha Shakil (talk | contribs)
CMEUser, nocaptcha
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==Astrocytoma==
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
|valign=top|
|valign=top|
|+
|+
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|'''Tumor'''}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Types of glioblastoma multiforme}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''History'''}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Genes}}
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Symptoms'''}}
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Characteristic Lab Findings'''}}
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Imaging'''}}
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Biopsy Findings'''}}
 
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Anaplastic Astrocytoma'''
:Primary​
| style="padding: 5px 5px; background: #F5F5F5;"|
*
*
*
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
* Seizures
*''[[Mdm2]]''
* Headache
*''[[PTEN]]''
* Neurologic deficits
*Gene on chromosome 10p
* Changes in mental status
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Secondary
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*  
*''IDH1''
*''[[p53]]''
*Gene on chromosome 10q
*Gene on chromosome 17p
*Gene on chromosome 19q
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Classic
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
* CT scan shows regions of low attenuation with positive mass effect
*''[[EGFR]]''
* Enhancement on CT is variable
*
* 
| style="padding: 5px 5px; background: #F5F5F5;" |
 
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
'''Oligoastrocytoma'''
:Proneural
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*  
*''[[TP53]]''
*  
*''PDGFRA''
*  
*''IDH1''
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
*
*
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
* Hypervascularity with diffuse multiple metastatic nodulation
| style="padding: 5px 5px; background: #F5F5F5;" |
* Solid sheets
* Uniform cuboidal cells
* Centrally located nuclei
* Stippled chromatin
* Granular eosinophilic cytoplasm
| style="padding: 5px 5px; background: #F5F5F5;" |
 
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
'''Pilocytic Astrocytoma'''
:Mesenchymal
| style="padding: 5px 5px; background: #F5F5F5;" |
* Epigastric abdominal pain
* Diarrhea
* Heartburn
* Hematemesis
| style="padding: 5px 5px; background: #F5F5F5;" |
* Elevated serum gastrin level
* Positive secretin stimulation test
| style="padding: 5px 5px; background: #F5F5F5;" |
* Small hypoattenuating nodule {{withorwithout}} calcification
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
* Lobular-trabecular pattern
*''[[NF-1]]''
* Gastrin+ tumor cells
* Infiltration of Brunner glands
| style="padding: 5px 5px; background: #F5F5F5;" |
|}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
{| border="1" cellpadding="5" cellspacing="0" align="center" class="sortable" style="text-align:center;"
|-
  ! Disease
  ! History and Symptoms
  ! Physical Examination
  ! Laboratory Findings
  ! Imaging
  ! Other Diagnostic Tests
  ! Features on Biopsy
  !
  !
  !
|-
  |'''Pilocytic Astrocytoma'''
  |
  |
  |
  |
  |
  |
  |
  |
|-
  |'''Diffuse Astrocytoma'''
  |Acute
  |10-20 minutes
  |Same as stable angina but often more severe
  |Same as stable angina
  |Same as stable angina but occurs with lower levels of exertion & rest
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
|-
  |'''Anaplastic Astrocytoma'''
  |Acute
  |Commonly > 20 minutes
  |Same as stable angina but often more severe
  |Same as stable angina
  |Same as stable angina but occurs with lower levels of exertion & rest
  |Usually unrelieved by nitroglycerine and rest
  |Same as stable angina
  |Same as stable angina
|-
  |'''[[Glioblastoma]]'''
  |Acute, recurrent episodes of angina
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
  |Same as stable angina
  |Not specific
|-
  |'''[[Oligodendroglioma]]'''
  |Sudden severe progressive pain (common) or chronic (rare)
  |Variable
  |Tearing, ripping sensation, knife like
  |Depends on area of dissection
  |Variable
  |Unrelenting pain, unrelieved by nitroglycerine and rest
  |Radiating to back, between shoulder blades (dissection in ascending aorta)
  |Trauma, Surgical manipulation, pregnancy, [[hypertension]], [[connective tissue disease]] like [[marfan's syndrome]] (cystic medial degeneration)
|-
  |'''[[Ependymoma]]'''
  |Acute or subacute
  |May last for hours to days
  |Sharp, localized
  |Retrosternal
  |Increases with coughing, deep breathing, supine position
  |Relieved by sitting up and leaning forward
  |Radiation to shoulder, neck, back abdomen
  |Not specific
|-
  |'''[[]]'''
|-
|}
|}

Revision as of 16:41, 19 November 2015
Types of glioblastoma multiforme Genes
Primary​
Secondary
  • IDH1
  • p53
  • Gene on chromosome 10q
  • Gene on chromosome 17p
  • Gene on chromosome 19q
Classic
Proneural
Mesenchymal
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