Essential thrombocytosis risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
Common risk factors in the development of essential thrombocytosis are presence of ''[[JAK2]]'' gene mutation, high white cell count >15 x | Common risk factors in the development of essential thrombocytosis are presence of ''[[JAK2]]'' gene mutation, high white cell count >15 x 10<sup>9</sup>/L at diagnosis, previous bone marrow fibrosis, age greater than 60 years and female sex.<ref name="pmid21106990">{{cite journal| author=Beer PA, Erber WN, Campbell PJ, Green AR| title=How I treat essential thrombocythemia. | journal=Blood | year= 2011 | volume= 117 | issue= 5 | pages= 1472-82 | pmid=21106990 | doi=10.1182/blood-2010-08-270033 | pmc=PMC3145107 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21106990 }} </ref> | ||
==Risk factors== | ==Risk factors== | ||
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*Other risk factors for essential thrombocytosis include: | *Other risk factors for essential thrombocytosis include: | ||
**Presence of ''[[JAK2]]'' mutation | **Presence of ''[[JAK2]]'' mutation | ||
**High white cell count of 15 x 10/L at the time of diagnosis | **High white cell count of 15 x 10<sup>9</sup>/L at the time of diagnosis | ||
**Previous history of thrombotic events | **Previous history of thrombotic events | ||
**Previous history of [[bone marrow]] fibrosis | **Previous history of [[bone marrow]] fibrosis | ||
Revision as of 19:11, 20 November 2015
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Differentiating Essential thrombocytosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Common risk factors in the development of essential thrombocytosis are presence of JAK2 gene mutation, high white cell count >15 x 109/L at diagnosis, previous bone marrow fibrosis, age greater than 60 years and female sex.[1]
Risk factors
- Most common risk factor in the development of essential thrombocytosis is age greater than 60 years.[1] Most patients go undiagnosed until late.
- Other risk factors for essential thrombocytosis include:
- Presence of JAK2 mutation
- High white cell count of 15 x 109/L at the time of diagnosis
- Previous history of thrombotic events
- Previous history of bone marrow fibrosis
- Female sex
References
- ↑ 1.0 1.1 Beer PA, Erber WN, Campbell PJ, Green AR (2011). "How I treat essential thrombocythemia". Blood. 117 (5): 1472–82. doi:10.1182/blood-2010-08-270033. PMC 3145107. PMID 21106990.