Sandbox: Bone DDx: Difference between revisions

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* 20-30 yo male
* Unerupted teeth
* Gradual dull bone pain at the tibial area
* Oral ulcers
* Leg swelling


* Painless mandibular mass
* Lower jaw crepitus on palpation
* Facial deformity


* Well-demarcated, eccentric/epicenteric, expansile, osteolytic, cortical lesion on X ray
* Located at the tibial diaphysis
* Areas of lysis interspersed with areas of sclerosis
* Lack of periosteal reaction


 
* Tall columnar cells with a palisaded nuclei and reverse polarization
* Biphasic tumor
* Subnuclear vacuolization
* Islands of epithelial cells found in a fibrous stroma
* Giant cells
* Fibro-osseous component includes spindle cells
* Subepithelial hyalinization
* Epithelial component includes nests of basaloid cells
 
* p53 gene mutations
* CK14 +ve
* CK19 +ve

Revision as of 14:53, 23 November 2015

  • Unerupted teeth
  • Oral ulcers
  • Painless mandibular mass
  • Lower jaw crepitus on palpation
  • Facial deformity


  • Tall columnar cells with a palisaded nuclei and reverse polarization
  • Subnuclear vacuolization
  • Giant cells
  • Subepithelial hyalinization
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