Sandbox: Bone DDx: Difference between revisions

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* 40-50 yo women
* History of hyperparathyroidism


* Well-defined, purely lytic lesions on X ray
* Located at the epiphysis
* Little reactive bone lesion
* Solid, cystic, or mixed component on MRI


* Abundant extracellular material
* Eosinophilic cytoplasm
* Calcifications surround cells nests
* Chickenwire appearance




* Fibrosis
* S100+ve
* Giant cells with round to oval nuclei and nucleoli
* Vimentin +ve
* Elevated number of osteoblast and osteoclast
 
* MEN1 gene
* RET oncogene

Revision as of 16:48, 23 November 2015

  • Located at the epiphysis
  • Abundant extracellular material
  • Eosinophilic cytoplasm
  • Calcifications surround cells nests
  • Chickenwire appearance


  • S100+ve
  • Vimentin +ve
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