Sandbox: Bone DDx: Difference between revisions

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* 10-30 yo patients
* 10-20 yo males
* Asymptomatic
* Extreme bone pain
* Pathological fracture
* Intermittent fever
* Maffuci syndrome and Ollier disease


* Widening of the bone
* Localized tenderness and swelling
* Limb-length discrepancy
* Angular deformity


* Located in the medullary cavity at the metaphyseal region
* Anemia and leukocytosis
* Small lytic lesions, sharply defined scalloped margin, and narrow zone of transition
* Increased sedimentation rate
* Expansion of the overlying cortex
* Rings and arcs of calcifications
* No periosteal reaction


* Lobules of hyaline cartilage
* Destructive bone lesions
* Surrounded by fibrous tissue and bone
* "Onion-skin" periosteal reaction
* Bony extension into the cartilage
 
* Myxoid change, hypercellularity, and binucleation
 
* Calcification, endochondral ossification, and necrosis
* Sheets of round, uniform, PAS +ve, small cells with a scant clear cytoplasm
* Round nuclei with indentations
* Homer-Wright rosettes
* Necrosis and hemorrhage
* Prominent vasculature and variable mitotic figures
 
* EWS/FLI-1 fusion gene
* t(11;22)(q24;q12)
* CD99 +ve
* FLI-1 +ve

Revision as of 13:45, 24 November 2015

  • 10-20 yo males
  • Extreme bone pain
  • Intermittent fever
  • Localized tenderness and swelling
  • Anemia and leukocytosis
  • Increased sedimentation rate
  • Destructive bone lesions
  • "Onion-skin" periosteal reaction


  • Sheets of round, uniform, PAS +ve, small cells with a scant clear cytoplasm
  • Round nuclei with indentations
  • Homer-Wright rosettes
  • Necrosis and hemorrhage
  • Prominent vasculature and variable mitotic figures
  • EWS/FLI-1 fusion gene
  • t(11;22)(q24;q12)
  • CD99 +ve
  • FLI-1 +ve
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