Sandbox: Bone DDx: Difference between revisions

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* 10-20 yo patients
* Asymptomatic incidental finding on imaging studies
* Bone pain and swelling


* 30-60 yo males
* Bone pain, progressive swelling, decreased range of motion
* Pathologic fracture
* Positive history of radiation exposure or bone infarct


* Fixed, firm mass to a localized area of tenderness
* Facial asymmetry, rib deformities, and leg-length discrepancy
* Neurologic or vascular defect


* Highly destructive with a wide zone of transition
* Located at the craniofacial bones, ribs, and proximal femur
* Expansile large soft tissue mass extending from the bone
* Periosteal reaction is uncommon
 
* Elevated mitotic activity
* Highly cellular fibroblastic proliferation
* Herring bone pattern and spindle cell lesions
* Long dark nuclei with increased granular chromatin
* Scant cytoplasm
 
* Vimentin +ve

Revision as of 14:41, 24 November 2015

  • 10-20 yo patients
  • Asymptomatic incidental finding on imaging studies
  • Bone pain and swelling


  • Facial asymmetry, rib deformities, and leg-length discrepancy
  • Located at the craniofacial bones, ribs, and proximal femur
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