Sandbox: Bone DDx: Difference between revisions

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* 1-5  yo children
* 20-30 yo males
* Asymptomatic
* Gradual, dull, and achy pain
* Minority of cases bone pain, swelling, and pathological fractures


* Painless, firm, swelling located at the anterior tibia
* Neurological deficit (cord compression)
* Anterior bowing of the tibia
* Scoliosis and torticollis


* Mainly located in the spine


* Well-circumscribed lesion
* Expansile lytic lesions with a rim of reactive sclerosis
* Intracortical osteolysis
* Internal calcification
* Sclerotic band (osteoblastic rimming)
* Cortical destruction, surrounding sclerosis, and periostitis
* Cortical expansion
* Secondary aneurysmal bone cyst
* Homogeneous lesion matrix




* Fibrous proliferation of polyhedral, round, or spindle cells
* Trabeculae of woven and osteoid bones
* Calcifications
* Surrounded by a single layer of osteoblasts
* Myxamatous matrix
* Multiple osteoclasts
* Psammomatoid growth patterns
* Loose fibrovascular stroma
* Intralesional hemorrhage

Revision as of 16:25, 24 November 2015

  • 20-30 yo males
  • Gradual, dull, and achy pain
  • Neurological deficit (cord compression)
  • Scoliosis and torticollis
  • Mainly located in the spine
  • Expansile lytic lesions with a rim of reactive sclerosis
  • Internal calcification
  • Cortical destruction, surrounding sclerosis, and periostitis
  • Secondary aneurysmal bone cyst


  • Trabeculae of woven and osteoid bones
  • Surrounded by a single layer of osteoblasts
  • Multiple osteoclasts
  • Loose fibrovascular stroma
  • Intralesional hemorrhage
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