Pineal choriocarcinoma: Difference between revisions
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==Overview== | ==Overview== | ||
*Pineal choriocarcinoma is a relatively rare malignant neoplasm and accounts for a small proportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. Pure pineal choriocarcinoma tumors secrete [[Human chorionic gonadotropin|β-HCG]].<ref name=overviewpc1>Intracranial choriocarcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-choriocarcinoma. Accessed on December 7, 2015</ref> | *Pineal choriocarcinoma is a relatively rare malignant neoplasm and accounts for a small proportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. Pure pineal choriocarcinoma tumors secrete [[Human chorionic gonadotropin|β-HCG]].<ref name=overviewpc1>Intracranial choriocarcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-choriocarcinoma. Accessed on December 7, 2015</ref> | ||
*On microscopic histopathological analysis, pineal choriocarcinoma is characterized by presence of intimately related [[syncytiotrophoblasts]] and [[cytotrophoblasts]] without formation of definite placental type villi. [[Syncytiotrophoblasts]] are large multi-nucleated cells with eosinophilic cytoplasm. They often surround the [[cytotrophoblasts]], reminiscent of their normal anatomical relationship in chorionic villi. [[Cytotrophoblasts]] are polyhedral, mononuclear cells with hyperchromatic [[nuclei]] and a clear or pale [[cytoplasm]].<ref name=histo1pc>Pathology of choriocarcinoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Choriocarcinoma. Accessed on December 7, 2015</ref> | *On microscopic histopathological analysis, pineal choriocarcinoma is characterized by presence of intimately related [[syncytiotrophoblast|syncytiotrophoblasts]] and [[cytotrophoblast|cytotrophoblasts]] without formation of definite placental type villi. [[syncytiotrophoblast|Syncytiotrophoblasts]] are large multi-nucleated cells with eosinophilic cytoplasm. They often surround the [[cytotrophoblast|cytotrophoblasts]], reminiscent of their normal anatomical relationship in chorionic villi. [[cytotrophoblast|Cytotrophoblasts]] are polyhedral, mononuclear cells with hyperchromatic [[nuclei]] and a clear or pale [[cytoplasm]].<ref name=histo1pc>Pathology of choriocarcinoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Choriocarcinoma. Accessed on December 7, 2015</ref> | ||
*Common complications of pineal choriocarcinoma include:<ref name="pmid3840234">{{cite journal| author=Kida Y, Banno M, Kanzaki M, Kobayashi T, Kageyama N| title=[Pineal choriocarcinoma presenting massive ventricular hemorrhage--a case report]. | journal=No Shinkei Geka | year= 1985 | volume= 13 | issue= 6 | pages= 641-5 | pmid=3840234 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/istopatcite&retmode=ref&cmd=prlinks&id=3840234 }} </ref> | *Common complications of pineal choriocarcinoma include:<ref name="pmid3840234">{{cite journal| author=Kida Y, Banno M, Kanzaki M, Kobayashi T, Kageyama N| title=[Pineal choriocarcinoma presenting massive ventricular hemorrhage--a case report]. | journal=No Shinkei Geka | year= 1985 | volume= 13 | issue= 6 | pages= 641-5 | pmid=3840234 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/istopatcite&retmode=ref&cmd=prlinks&id=3840234 }} </ref> | ||
:*CSF [[metastasis]] | :*CSF [[metastasis]] | ||
Revision as of 15:41, 7 December 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Synonyms and keywords: Pineal embryonal cell carcinoma; Pineal gland tumor; Brain tumor
Overview
- Pineal choriocarcinoma is a relatively rare malignant neoplasm and accounts for a small proportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. Pure pineal choriocarcinoma tumors secrete β-HCG.[1]
- On microscopic histopathological analysis, pineal choriocarcinoma is characterized by presence of intimately related syncytiotrophoblasts and cytotrophoblasts without formation of definite placental type villi. Syncytiotrophoblasts are large multi-nucleated cells with eosinophilic cytoplasm. They often surround the cytotrophoblasts, reminiscent of their normal anatomical relationship in chorionic villi. Cytotrophoblasts are polyhedral, mononuclear cells with hyperchromatic nuclei and a clear or pale cytoplasm.[2]
- Common complications of pineal choriocarcinoma include:[3]
- CSF metastasis
- Ventricular hemorrhage
References
- ↑ Intracranial choriocarcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-choriocarcinoma. Accessed on December 7, 2015
- ↑ Pathology of choriocarcinoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Choriocarcinoma. Accessed on December 7, 2015
- ↑ Kida Y, Banno M, Kanzaki M, Kobayashi T, Kageyama N (1985). "[Pineal choriocarcinoma presenting massive ventricular hemorrhage--a case report]". No Shinkei Geka. 13 (6): 641–5. PMID 3840234.