Adenocarcinoma of the lung classification: Difference between revisions
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==Overview== | ==Overview== | ||
== Classification == | == Classification == | ||
Adenocarcinomas are highly heterogeneous tumors. Several major histological subtypes are currently recognized by the WHO<ref name="pmid4209392">{{cite journal| author=Hawkey CM| title=The relationship between blood coagulation and thrombosis and atherosclerosis in man, monkeys and carnivores. | journal=Thromb Diath Haemorrh | year= 1974 | volume= 31 | issue= 1 | pages= 103-18 | pmid=4209392 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4209392 }} </ref> and IASLC/ATS/ERS<ref name="pmid21828029">{{Cite journal | pmid = 21828029| year = 2012| author1 = Van Schil| first1 = P. E.| title = Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification| journal = European Respiratory Journal| volume = 39| issue = 2| pages = 478-86| last2 = Asamura| first2 = H| last3 = Rusch| first3 = V. W.| last4 = Mitsudomi| first4 = T| last5 = Tsuboi| first5 = M| last6 = Brambilla| first6 = E| last7 = Travis| first7 = W. D.| doi = 10.1183/09031936.00027511}}</ref><ref>{{Cite journal | pmid = 21804158| year = 2011| author1 = Travis| first1 = W. D.| title = Paradigm shifts in lung cancer as defined in the new IASLC/ATS/ERS lung adenocarcinoma classification| journal = European Respiratory Journal| volume = 38| issue = 2| pages = 239-43| last2 = Brambilla| first2 = E| last3 = Van Schil| first3 = P| last4 = Scagliotti| first4 = G. V.| last5 = Huber| first5 = R. M.| last6 = Sculier| first6 = J. P.| last7 = Vansteenkiste| first7 = J| last8 = Nicholson| first8 = A. G.| doi = 10.1183/09031936.00026711}}</ref><ref>{{Cite journal | pmid = 18951650| year = 2009| author1 = Vazquez| first1 = M| title = Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: Histopathologic features and their prognostic implications| journal = Lung Cancer| volume = 64| issue = 2| pages = 148-54| last2 = Carter| first2 = D| last3 = Brambilla| first3 = E| last4 = Gazdar| first4 = A| last5 = Noguchi| first5 = M| last6 = Travis| first6 = W. D.| last7 = Huang| first7 = Y| last8 = Zhang| first8 = L| last9 = Yip| first9 = R| last10 = Yankelevitz| first10 = D. F.| last11 = Henschke| first11 = C. I.| author12 = International Early Lung Cancer Action Program Investigators| doi = 10.1016/j.lungcan.2008.08.009| pmc = 2849638}}</ref> | * Adenocarcinomas are highly heterogeneous tumors. Several major histological subtypes are currently recognized by the WHO<ref name="pmid4209392">{{cite journal| author=Hawkey CM| title=The relationship between blood coagulation and thrombosis and atherosclerosis in man, monkeys and carnivores. | journal=Thromb Diath Haemorrh | year= 1974 | volume= 31 | issue= 1 | pages= 103-18 | pmid=4209392 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4209392 }} </ref> and IASLC/ATS/ERS<ref name="pmid21828029">{{Cite journal | pmid = 21828029| year = 2012| author1 = Van Schil| first1 = P. E.| title = Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification| journal = European Respiratory Journal| volume = 39| issue = 2| pages = 478-86| last2 = Asamura| first2 = H| last3 = Rusch| first3 = V. W.| last4 = Mitsudomi| first4 = T| last5 = Tsuboi| first5 = M| last6 = Brambilla| first6 = E| last7 = Travis| first7 = W. D.| doi = 10.1183/09031936.00027511}}</ref><ref>{{Cite journal | pmid = 21804158| year = 2011| author1 = Travis| first1 = W. D.| title = Paradigm shifts in lung cancer as defined in the new IASLC/ATS/ERS lung adenocarcinoma classification| journal = European Respiratory Journal| volume = 38| issue = 2| pages = 239-43| last2 = Brambilla| first2 = E| last3 = Van Schil| first3 = P| last4 = Scagliotti| first4 = G. V.| last5 = Huber| first5 = R. M.| last6 = Sculier| first6 = J. P.| last7 = Vansteenkiste| first7 = J| last8 = Nicholson| first8 = A. G.| doi = 10.1183/09031936.00026711}}</ref><ref>{{Cite journal | pmid = 18951650| year = 2009| author1 = Vazquez| first1 = M| title = Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: Histopathologic features and their prognostic implications| journal = Lung Cancer| volume = 64| issue = 2| pages = 148-54| last2 = Carter| first2 = D| last3 = Brambilla| first3 = E| last4 = Gazdar| first4 = A| last5 = Noguchi| first5 = M| last6 = Travis| first6 = W. D.| last7 = Huang| first7 = Y| last8 = Zhang| first8 = L| last9 = Yip| first9 = R| last10 = Yankelevitz| first10 = D. F.| last11 = Henschke| first11 = C. I.| author12 = International Early Lung Cancer Action Program Investigators| doi = 10.1016/j.lungcan.2008.08.009| pmc = 2849638}}</ref> | ||
In as many as 80% of tumors that are extensively sampled, components of more than one of these subtypes will be recognized. Using increments of 5% to describe the amount of each subtype present, the predominant subtype is used to classify the whole tumor.<ref>{{Cite journal | pmid = 21252716| year = 2011| author1 = Travis| first1 = W. D.| title = International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma| journal = Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer| volume = 6| issue = 2| pages = 244–85| last2 = Brambilla| first2 = E| last3 = Noguchi| first3 = M| last4 = Nicholson| first4 = A. G.| last5 = Geisinger| first5 = K. R.| last6 = Yatabe| first6 = Y| last7 = Beer| first7 = D. G.| last8 = Powell| first8 = C. A.| last9 = Riely| first9 = G. J.| last10 = Van Schil| first10 = P. E.| last11 = Garg| first11 = K| last12 = Austin| first12 = J. H.| last13 = Asamura| first13 = H| last14 = Rusch| first14 = V. W.| last15 = Hirsch| first15 = F. R.| last16 = Scagliotti| first16 = G| last17 = Mitsudomi| first17 = T| last18 = Huber| first18 = R. M.| last19 = Ishikawa| first19 = Y| last20 = Jett| first20 = J| last21 = Sanchez-Cespedes| first21 = M| last22 = Sculier| first22 = J. P.| last23 = Takahashi| first23 = T| last24 = Tsuboi| first24 = M| last25 = Vansteenkiste| first25 = J| last26 = Wistuba| first26 = I| last27 = Yang| first27 = P. C.| last28 = Aberle| first28 = D| last29 = Brambilla| first29 = C| last30 = Flieder| first30 = D| display-authors = 29| doi = 10.1097/JTO.0b013e318206a221}}</ref> The predominant subtype is prognostic for survival after complete resection.<ref>{{Cite journal | pmid = 21642859| year = 2011| author1 = Russell| first1 = P. A.| title = Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung adenocarcinoma classification| journal = Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer| volume = 6| issue = 9| pages = 1496–504| last2 = Wainer| first2 = Z| last3 = Wright| first3 = G. M.| last4 = Daniels| first4 = M| last5 = Conron| first5 = M| last6 = Williams| first6 = R. A.| doi = 10.1097/JTO.0b013e318221f701}}</ref> | * In as many as 80% of tumors that are extensively sampled, components of more than one of these subtypes will be recognized. Using increments of 5% to describe the amount of each subtype present, the predominant subtype is used to classify the whole tumor.<ref>{{Cite journal | pmid = 21252716| year = 2011| author1 = Travis| first1 = W. D.| title = International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma| journal = Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer| volume = 6| issue = 2| pages = 244–85| last2 = Brambilla| first2 = E| last3 = Noguchi| first3 = M| last4 = Nicholson| first4 = A. G.| last5 = Geisinger| first5 = K. R.| last6 = Yatabe| first6 = Y| last7 = Beer| first7 = D. G.| last8 = Powell| first8 = C. A.| last9 = Riely| first9 = G. J.| last10 = Van Schil| first10 = P. E.| last11 = Garg| first11 = K| last12 = Austin| first12 = J. H.| last13 = Asamura| first13 = H| last14 = Rusch| first14 = V. W.| last15 = Hirsch| first15 = F. R.| last16 = Scagliotti| first16 = G| last17 = Mitsudomi| first17 = T| last18 = Huber| first18 = R. M.| last19 = Ishikawa| first19 = Y| last20 = Jett| first20 = J| last21 = Sanchez-Cespedes| first21 = M| last22 = Sculier| first22 = J. P.| last23 = Takahashi| first23 = T| last24 = Tsuboi| first24 = M| last25 = Vansteenkiste| first25 = J| last26 = Wistuba| first26 = I| last27 = Yang| first27 = P. C.| last28 = Aberle| first28 = D| last29 = Brambilla| first29 = C| last30 = Flieder| first30 = D| display-authors = 29| doi = 10.1097/JTO.0b013e318206a221}}</ref> The predominant subtype is prognostic for survival after complete resection.<ref>{{Cite journal | pmid = 21642859| year = 2011| author1 = Russell| first1 = P. A.| title = Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung adenocarcinoma classification| journal = Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer| volume = 6| issue = 9| pages = 1496–504| last2 = Wainer| first2 = Z| last3 = Wright| first3 = G. M.| last4 = Daniels| first4 = M| last5 = Conron| first5 = M| last6 = Williams| first6 = R. A.| doi = 10.1097/JTO.0b013e318221f701}}</ref> | ||
'''2004 WHO classification''' | '''2004 WHO classification''' | ||
Revision as of 20:15, 9 December 2015
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Adenocarcinoma of the Lung Microchapters |
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Differentiating Adenocarcinoma of the Lung from other Diseases |
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Adenocarcinoma of the lung classification On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Classification
- Adenocarcinomas are highly heterogeneous tumors. Several major histological subtypes are currently recognized by the WHO[1] and IASLC/ATS/ERS[2][3][4]
- In as many as 80% of tumors that are extensively sampled, components of more than one of these subtypes will be recognized. Using increments of 5% to describe the amount of each subtype present, the predominant subtype is used to classify the whole tumor.[5] The predominant subtype is prognostic for survival after complete resection.[6]
2004 WHO classification
- Mixed subtype
- Acinar
- Papillary
- Bronchioloalveolar carcinoma
- Non mucinous
- Mucinous
- Mixed
- Solid adenocarcinoma
- Colloid
- Fetal
- Mucinous cystadenocarcinoma
- Signet-ring
- Clear-cell
IASLC/ATS/ERS classification
- Pre-invasive lesions
- Atypical adenomatous hyperplasia
- Adenocarcinoma in situ of lung
- Non-mucinous
- Mucinous
- Mixed
- Minimally Invasive Adenocarcinoma
- Non-mucinous
- Mucinous
- Mixed
- Invasive adenocarcinomas
- Lepidic predominant
- Acinar predominant
- Papillary predominant
- Micropapillary predominant
- Solid predominant with mucin production
- Variants of invasive adenocarcinomas
- Invasive mucinous adenocarcinoma
- Colloid
- Fetal
- Enteric
References
- ↑ Hawkey CM (1974). "The relationship between blood coagulation and thrombosis and atherosclerosis in man, monkeys and carnivores". Thromb Diath Haemorrh. 31 (1): 103–18. PMID 4209392.
- ↑ Van Schil, P. E.; Asamura, H; Rusch, V. W.; Mitsudomi, T; Tsuboi, M; Brambilla, E; Travis, W. D. (2012). "Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification". European Respiratory Journal. 39 (2): 478–86. doi:10.1183/09031936.00027511. PMID 21828029.
- ↑ Travis, W. D.; Brambilla, E; Van Schil, P; Scagliotti, G. V.; Huber, R. M.; Sculier, J. P.; Vansteenkiste, J; Nicholson, A. G. (2011). "Paradigm shifts in lung cancer as defined in the new IASLC/ATS/ERS lung adenocarcinoma classification". European Respiratory Journal. 38 (2): 239–43. doi:10.1183/09031936.00026711. PMID 21804158.
- ↑ Vazquez, M; Carter, D; Brambilla, E; Gazdar, A; Noguchi, M; Travis, W. D.; Huang, Y; Zhang, L; Yip, R; Yankelevitz, D. F.; Henschke, C. I.; International Early Lung Cancer Action Program Investigators (2009). "Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: Histopathologic features and their prognostic implications". Lung Cancer. 64 (2): 148–54. doi:10.1016/j.lungcan.2008.08.009. PMC 2849638. PMID 18951650.
- ↑ Travis, W. D.; Brambilla, E; Noguchi, M; Nicholson, A. G.; Geisinger, K. R.; Yatabe, Y; Beer, D. G.; Powell, C. A.; Riely, G. J.; Van Schil, P. E.; Garg, K; Austin, J. H.; Asamura, H; Rusch, V. W.; Hirsch, F. R.; Scagliotti, G; Mitsudomi, T; Huber, R. M.; Ishikawa, Y; Jett, J; Sanchez-Cespedes, M; Sculier, J. P.; Takahashi, T; Tsuboi, M; Vansteenkiste, J; Wistuba, I; Yang, P. C.; Aberle, D; Brambilla, C; et al. (2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma". Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 6 (2): 244–85. doi:10.1097/JTO.0b013e318206a221. PMID 21252716.
- ↑ Russell, P. A.; Wainer, Z; Wright, G. M.; Daniels, M; Conron, M; Williams, R. A. (2011). "Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung adenocarcinoma classification". Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 6 (9): 1496–504. doi:10.1097/JTO.0b013e318221f701. PMID 21642859.