Linitis plastica screening: Difference between revisions
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==Screening== | ==Screening== | ||
*Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for ''CDH1'' gene mutations.<ref name=me>Hereditary diffuse gastric cancer. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer#definition Accessed on December 10, 2015</ref> | *Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for ''CDH1'' gene mutations.<ref name=me>Hereditary diffuse gastric cancer. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer#definition Accessed on December 10, 2015</ref> | ||
*Indication for prophylactic gastrectomy include CDH1 positive patients.<ref name="pmid20719348">{{cite journal| author=Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS| title=Prophylactic total gastrectomy for individuals with germline CDH1 mutation. | journal=Surgery | year= 2011 | volume= 149 | issue= 3 | pages= 347-55 | pmid=20719348 | doi=10.1016/j.surg.2010.07.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20719348 }} </ref> | *Indication for prophylactic [[gastrectomy]] include CDH1 positive patients.<ref name="pmid20719348">{{cite journal| author=Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS| title=Prophylactic total gastrectomy for individuals with germline CDH1 mutation. | journal=Surgery | year= 2011 | volume= 149 | issue= 3 | pages= 347-55 | pmid=20719348 | doi=10.1016/j.surg.2010.07.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20719348 }} </ref> | ||
**The disease penetrance for the hereditary form is 80%, resulting in a very high risk of developing the cancer. | **The disease [[penetrance]] for the hereditary form is 80%, resulting in a very high risk of developing the cancer. | ||
==References== | ==References== | ||
Revision as of 02:06, 14 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for CDH1 gene mutations.[1]
Screening
- Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for CDH1 gene mutations.[1]
- Indication for prophylactic gastrectomy include CDH1 positive patients.[2]
- The disease penetrance for the hereditary form is 80%, resulting in a very high risk of developing the cancer.
References
- ↑ 1.0 1.1 Hereditary diffuse gastric cancer. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer#definition Accessed on December 10, 2015
- ↑ Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS (2011). "Prophylactic total gastrectomy for individuals with germline CDH1 mutation". Surgery. 149 (3): 347–55. doi:10.1016/j.surg.2010.07.005. PMID 20719348.