Adenocarcinoma of the lung causes: Difference between revisions
Jump to navigation
Jump to search
Shanshan Cen (talk | contribs) Created page with "__NOTOC__ {{Adenocarcinoma of the lung}} {{CMG}}; {{AE}} {{SC}} ==Overview== ==References== {{reflist|2}} {{WikiDoc Help Menu}} {{WikiDoc Sources}} Category:Disease C..." |
Shanshan Cen (talk | contribs) No edit summary |
||
| Line 3: | Line 3: | ||
{{CMG}}; {{AE}} {{SC}} | {{CMG}}; {{AE}} {{SC}} | ||
==Overview== | ==Overview== | ||
Common causes of adenocarcinoma of the lung include chromosomal rearrangements and genetic mutations.<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref> | |||
==Causes== | |||
'''Chromosomal rearrangements''' | |||
* Three membrane associated tyrosine kinase receptors are recurrently involved in rearrangements in adenocarcinomas: [[anaplastic lymphoma kinase|ALK]], ROS1, and RET, and more than eighty other translocations have also been reported in adenocarcinomas of the lung.<ref>http://atlasgeneticsoncology.org/Tumors/TranslocLungAdenocarcID6751.html</ref> | |||
'''Genetic mutations''' | |||
* Genes involved in the pathogenesis of adenocarcinoma of the lung include:<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref> | |||
:* [[epidermal growth factor receptor|EGFR]] (20%) | |||
:* [[HER2]] (2%) | |||
:* [[KRAS]] | |||
:* [[anaplastic lymphoma kinase|ALK]] | |||
:* [[BRAF]] | |||
:* PIK3CA | |||
:* [[C-Met|MET]] (1%, associated with resistant disease) | |||
:* ROS1 | |||
==References== | ==References== | ||
Revision as of 19:23, 14 December 2015
|
Adenocarcinoma of the Lung Microchapters |
|
Differentiating Adenocarcinoma of the Lung from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Adenocarcinoma of the lung causes On the Web |
|
American Roentgen Ray Society Images of Adenocarcinoma of the lung causes |
|
Risk calculators and risk factors for Adenocarcinoma of the lung causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Common causes of adenocarcinoma of the lung include chromosomal rearrangements and genetic mutations.[1]
Causes
Chromosomal rearrangements
- Three membrane associated tyrosine kinase receptors are recurrently involved in rearrangements in adenocarcinomas: ALK, ROS1, and RET, and more than eighty other translocations have also been reported in adenocarcinomas of the lung.[2]
Genetic mutations
- Genes involved in the pathogenesis of adenocarcinoma of the lung include:[3]
References
- ↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
- ↑ http://atlasgeneticsoncology.org/Tumors/TranslocLungAdenocarcID6751.html
- ↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.